Behavioral and biochemical effects of Kaixin-San, a traditional Chinese medicinal empirical formula

Yuan Hu; Ping Liu; Dai Hong Guo; Khalid Rahman; Dong Xiao Wang; Meng Li Chen; Ting Ting Xie

doi:10.1002/ddr.20252

Behavioral and biochemical effects of Kaixin-San, a traditional Chinese medicinal empirical formula

Yuan Hu, Ping Liu, Dai Hong Guo, Khalid Rahman, Dong Xiao Wang, Meng Li Chen, Ting Ting Xie

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

(Table Presented) Kaixin-San (KXS), a traditional Chinese medicine, has been used in the treatment of depression. The present study was undertaken to investigate the effects of an ethanolic extract of KXS (KXSE) in mouse models of depression, the forced swim test (FST) and tail suspension test (TST). At doses of 500 mg/kg, KXS-E reduced the immobility time in the FST and TST in mice 30 min after treatment. The main monoamine neurotransmitters and their metabolites in mouse brain regions were also simultaneously determined by HPLC-ECD. KXS-E not only increased the concentrations of 5-HT and NE in whole brain, but also reduced the ratio of 5-HIAA/5-HT, slowing down 5-HT metabolism as compared with mice treated with vehicle+stress. In conclusion, KXS-E produced antidepressant-like effects in a mouse model with a mechanism of action that may involve increased 5-HT and NE in the mouse brain.

Original language	English
Pages (from-to)	267-271
Number of pages	5
Journal	Drug Development Research
Volume	69
Issue number	5
DOIs	https://doi.org/10.1002/ddr.20252
State	Published - Aug 2008
Externally published	Yes

Keywords

Antidepressant
Forced swimming test
Kaixin-San
Neuro-transmitters
Tail suspension test

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10.1002/ddr.20252

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title = "Behavioral and biochemical effects of Kaixin-San, a traditional Chinese medicinal empirical formula",

abstract = "(Table Presented) Kaixin-San (KXS), a traditional Chinese medicine, has been used in the treatment of depression. The present study was undertaken to investigate the effects of an ethanolic extract of KXS (KXSE) in mouse models of depression, the forced swim test (FST) and tail suspension test (TST). At doses of 500 mg/kg, KXS-E reduced the immobility time in the FST and TST in mice 30 min after treatment. The main monoamine neurotransmitters and their metabolites in mouse brain regions were also simultaneously determined by HPLC-ECD. KXS-E not only increased the concentrations of 5-HT and NE in whole brain, but also reduced the ratio of 5-HIAA/5-HT, slowing down 5-HT metabolism as compared with mice treated with vehicle+stress. In conclusion, KXS-E produced antidepressant-like effects in a mouse model with a mechanism of action that may involve increased 5-HT and NE in the mouse brain.",

keywords = "Antidepressant, Forced swimming test, Kaixin-San, Neuro-transmitters, Tail suspension test",

author = "Yuan Hu and Ping Liu and Guo, {Dai Hong} and Khalid Rahman and Wang, {Dong Xiao} and Chen, {Meng Li} and Xie, {Ting Ting}",

year = "2008",

month = aug,

doi = "10.1002/ddr.20252",

language = "English",

volume = "69",

pages = "267--271",

journal = "Drug Development Research",

issn = "0272-4391",

publisher = "John Wiley & Sons Inc.",

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T1 - Behavioral and biochemical effects of Kaixin-San, a traditional Chinese medicinal empirical formula

AU - Hu, Yuan

AU - Liu, Ping

AU - Guo, Dai Hong

AU - Rahman, Khalid

AU - Wang, Dong Xiao

AU - Chen, Meng Li

AU - Xie, Ting Ting

PY - 2008/8

Y1 - 2008/8

N2 - (Table Presented) Kaixin-San (KXS), a traditional Chinese medicine, has been used in the treatment of depression. The present study was undertaken to investigate the effects of an ethanolic extract of KXS (KXSE) in mouse models of depression, the forced swim test (FST) and tail suspension test (TST). At doses of 500 mg/kg, KXS-E reduced the immobility time in the FST and TST in mice 30 min after treatment. The main monoamine neurotransmitters and their metabolites in mouse brain regions were also simultaneously determined by HPLC-ECD. KXS-E not only increased the concentrations of 5-HT and NE in whole brain, but also reduced the ratio of 5-HIAA/5-HT, slowing down 5-HT metabolism as compared with mice treated with vehicle+stress. In conclusion, KXS-E produced antidepressant-like effects in a mouse model with a mechanism of action that may involve increased 5-HT and NE in the mouse brain.

AB - (Table Presented) Kaixin-San (KXS), a traditional Chinese medicine, has been used in the treatment of depression. The present study was undertaken to investigate the effects of an ethanolic extract of KXS (KXSE) in mouse models of depression, the forced swim test (FST) and tail suspension test (TST). At doses of 500 mg/kg, KXS-E reduced the immobility time in the FST and TST in mice 30 min after treatment. The main monoamine neurotransmitters and their metabolites in mouse brain regions were also simultaneously determined by HPLC-ECD. KXS-E not only increased the concentrations of 5-HT and NE in whole brain, but also reduced the ratio of 5-HIAA/5-HT, slowing down 5-HT metabolism as compared with mice treated with vehicle+stress. In conclusion, KXS-E produced antidepressant-like effects in a mouse model with a mechanism of action that may involve increased 5-HT and NE in the mouse brain.

KW - Antidepressant

KW - Forced swimming test

KW - Kaixin-San

KW - Neuro-transmitters

KW - Tail suspension test

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DO - 10.1002/ddr.20252

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SN - 0272-4391

VL - 69

SP - 267

EP - 271

JO - Drug Development Research

JF - Drug Development Research

IS - 5

ER -

Behavioral and biochemical effects of Kaixin-San, a traditional Chinese medicinal empirical formula

Abstract

Keywords

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