Basis for the acquisition of malignant potential by mouse cells cultivated in vitro

Stuart A. Aaronson; George J. Todaro

doi:10.1126/science.162.3857.1024

Basis for the acquisition of malignant potential by mouse cells cultivated in vitro

Stuart A. Aaronson, George J. Todaro

Research output: Contribution to journal › Article › peer-review

320 Scopus citations

Abstract

Balb/c mouse embryo lines maintained in culture for over 200 generations under conditions that minimize cell-cell contact do not become tumorigenic. Lines cultivated under conditions where there is extensive cell contact become tumor-producing within 30 generations. The tissue-culture property that correlates best with tumorigenicity is the loss of contact inhibition of cell division.

Original language	English
Pages (from-to)	1024-1026
Number of pages	3
Journal	Science
Volume	162
Issue number	3857
DOIs	https://doi.org/10.1126/science.162.3857.1024
State	Published - 1968
Externally published	Yes

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title = "Basis for the acquisition of malignant potential by mouse cells cultivated in vitro",

abstract = "Balb/c mouse embryo lines maintained in culture for over 200 generations under conditions that minimize cell-cell contact do not become tumorigenic. Lines cultivated under conditions where there is extensive cell contact become tumor-producing within 30 generations. The tissue-culture property that correlates best with tumorigenicity is the loss of contact inhibition of cell division.",

author = "Aaronson, {Stuart A.} and Todaro, {George J.}",

year = "1968",

doi = "10.1126/science.162.3857.1024",

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AU - Aaronson, Stuart A.

AU - Todaro, George J.

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AB - Balb/c mouse embryo lines maintained in culture for over 200 generations under conditions that minimize cell-cell contact do not become tumorigenic. Lines cultivated under conditions where there is extensive cell contact become tumor-producing within 30 generations. The tissue-culture property that correlates best with tumorigenicity is the loss of contact inhibition of cell division.

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JO - Science

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Basis for the acquisition of malignant potential by mouse cells cultivated in vitro

Abstract

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