Baseline lower extremity strength and subsequent decline in functional performance at 6-year follow-up in persons with lower extremity peripheral arterial disease

Seth D. Herman, Kiang Liu, Lu Tian, Jack M. Guralnik, Luigi Ferrucci, Michael H. Criqui, Yihua Liao, Mary M. McDermott

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

OBJECTIVES: To evaluate associations between baseline lower extremity strength and decline in functional performance over 6 years of follow-up in men and women with lower extremity peripheral arterial disease (PAD). DESIGN: Prospective observational study. SETTING: Three Chicago-area hospitals. PARTICIPANTS: Three hundred seventy-four men and women with PAD. MEASUREMENTS: Baseline isometric hip extension, hip flexion, knee flexion, and knee extension strength were measured using a musculoskeletal fitness evaluation chair. Usual and fastest-paced 4-m walking speed, 6-minute walk, and Short Physical Performance Battery (SPPB) were assessed at baseline and annually thereafter. Analyses were adjusted for age, sex, race, ankle-brachial index (ABI), comorbidities, and other confounders. RESULTS: In women with PAD, weaker baseline hip and knee flexion strength were associated with faster average annual decline in usual-pace 4-m walking speed (P trend <.001 and.02, respectively) and SPPB (P trend=.02 and.01, respectively). In women, weaker hip extension strength was associated with faster decline in usual-pace 4-m walking speed and SPPB (P trend=.01 and <.01, respectively). There were no significant associations between baseline strength and decline in 6-minute walk in women. There were no significant associations between any baseline strength measure and functional decline in men. CONCLUSION: Weaker baseline leg strength is associated with faster functional decline in nonendurance measures of functional performance in women with PAD but not in men with PAD.

Original languageEnglish
Pages (from-to)2246-2252
Number of pages7
JournalJournal of the American Geriatrics Society
Volume57
Issue number12
DOIs
StatePublished - Dec 2009
Externally publishedYes

Keywords

  • Intermittent claudication
  • Peripheral arterial disease
  • Physical functioning
  • SPPB

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