TY - JOUR
T1 - Base editors dissect genetic variants in human hematopoietic cells on a large scale
AU - Papapetrou, Eirini P.
N1 - Funding Information:
E.P.P. is supported by US National Institutes of Health (NIH) grants R01CA271418 , R01CA260711 , and R01CA271331 , by a Leukemia and Lymphoma Society (LLS) Scholar Award, by an Edward P. Evans Foundation Discovery Research Grant, by an LLS Blood Cancer Discoveries Grant, and by a 2021 AACR-MPM Oncology Charitable Foundation Transformative Cancer Research Grant (grant number 21-20-45-PAPA ).
Funding Information:
E.P.P. is supported by US National Institutes of Health (NIH) grants R01CA271418, R01CA260711, and R01CA271331, by a Leukemia and Lymphoma Society (LLS) Scholar Award, by an Edward P. Evans Foundation Discovery Research Grant, by an LLS Blood Cancer Discoveries Grant, and by a 2021 AACR-MPM Oncology Charitable Foundation Transformative Cancer Research Grant (grant number 21-20-45-PAPA). The author declares no competing interests.
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/7
Y1 - 2023/7
N2 - In a recent study, Martin-Rufino and colleagues combined massively parallel base editing in primary human hematopoietic stem and progenitor cells (HSPCs) with functional and single-cell transcriptomic readouts. A series of proof-of-principle experiments highlight the breadth of applications made possible with this approach, which range from gene therapy and immunotherapy, to characterizing single nucleotide variants.
AB - In a recent study, Martin-Rufino and colleagues combined massively parallel base editing in primary human hematopoietic stem and progenitor cells (HSPCs) with functional and single-cell transcriptomic readouts. A series of proof-of-principle experiments highlight the breadth of applications made possible with this approach, which range from gene therapy and immunotherapy, to characterizing single nucleotide variants.
UR - http://www.scopus.com/inward/record.url?scp=85161676129&partnerID=8YFLogxK
U2 - 10.1016/j.it.2023.05.009
DO - 10.1016/j.it.2023.05.009
M3 - Short survey
C2 - 37316391
AN - SCOPUS:85161676129
SN - 1471-4906
VL - 44
SP - 490
EP - 492
JO - Trends in Immunology
JF - Trends in Immunology
IS - 7
ER -