Bartter's syndrome: A dilemma of cause and effect

E. Bourke, V. Delaney

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Six interrelated abnormalities of Bartter's syndrome are analyzed - juxtaglomerular hyperplasia, angiotensin resistance, altered kallikrein-kinin systems, hyperprostaglandinuria, hypokalemia, and chloride-losing nephropathy. Arguments are advanced that any one of these could be the proximate cause and result in all the others. By the same token, each abnormality could be a consequence of any of the others and, furthermore, modulate the others by negative or positive feedback. Despite many recent insights, available data do not permit a definitive conclusion as to the locus of the primary abnormality. Rather, the syndrome presents as a remarkable biological counterpart to an electronic integrated circuit. The altered physiology of Bartter's syndrome is reviewed and the pathogenesis of the syndrome analyzed in the light of recent literature.

Original languageEnglish
Pages (from-to)177-186
Number of pages10
Issue number4-5
StatePublished - 1981
Externally publishedYes


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