Barriers to ideal outcomes after pediatric liver transplantation

Vicky Lee Ng, George V. Mazariegos, Beau Kelly, Simon Horslen, Sue V. McDiarmid, John C. Magee, Kathleen M. Loomes, Ryan T. Fischer, Shikha S. Sundaram, Jennifer C. Lai, Helen S. Te, John C. Bucuvalas

Research output: Contribution to journalComment/debate

29 Scopus citations

Abstract

Long-term survival for children who undergo LT is now the rule rather than the exception. However, a focus on the outcome of patient or graft survival rates alone provides an incomplete and limited view of life for patients who undergo LT as an infant, child, or teen. The paradigm has now appropriately shifted to opportunities focused on our overarching goals of “surviving and thriving” with long-term allograft health, freedom of complications from long-term immunosuppression, self-reported well-being, and global functional health. Experts within the liver transplant community highlight clinical gaps and potential barriers at each of the pretransplant, intra-operative, early-, medium-, and long-term post-transplant stages toward these broader mandates. Strategies including clinical research, innovation, and quality improvement targeting both traditional as well as PRO are outlined and, if successfully leveraged and conducted, would improve outcomes for recipients of pediatric LT.

Original languageEnglish
Article numbere13537
JournalPediatric Transplantation
Volume23
Issue number6
DOIs
StatePublished - 2019
Externally publishedYes

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