TY - JOUR
T1 - Balancing histone methylation activities in psychiatric disorders
AU - Peter, Cyril Jayakumar
AU - Akbarian, Schahram
N1 - Funding Information:
The work conducted in the author's laboratory is supported by grants from the National Institutes of Health, the International Mental Health Research Organization and Autism Speaks.
PY - 2011/7
Y1 - 2011/7
N2 - Alterations in histone lysine methylation and other epigenetic regulators of gene expression contribute to changes in brain transcriptomes in mood and psychosis spectrum disorders, including depression and schizophrenia. Genetic association studies and animal models implicate multiple lysine methyltransferases and demethylases in the neurobiology of emotion and cognition. Here, we review the role of histone lysine methylation and transcriptional regulation in normal and diseased neurodevelopment and discuss various methyltransferases and demethylases as potential therapeutic targets in the treatment of neuropsychiatric disease.
AB - Alterations in histone lysine methylation and other epigenetic regulators of gene expression contribute to changes in brain transcriptomes in mood and psychosis spectrum disorders, including depression and schizophrenia. Genetic association studies and animal models implicate multiple lysine methyltransferases and demethylases in the neurobiology of emotion and cognition. Here, we review the role of histone lysine methylation and transcriptional regulation in normal and diseased neurodevelopment and discuss various methyltransferases and demethylases as potential therapeutic targets in the treatment of neuropsychiatric disease.
UR - http://www.scopus.com/inward/record.url?scp=79960276209&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2011.02.003
DO - 10.1016/j.molmed.2011.02.003
M3 - Review article
C2 - 21429800
AN - SCOPUS:79960276209
SN - 1471-4914
VL - 17
SP - 372
EP - 379
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 7
ER -