Badimon perfusion chamber: An ex vivo model of thrombosis

M. Urooj Zafar, Carlos G. Santos-Gallego, Lina Badimon, Juan J. Badimon

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

26 Scopus citations

Abstract

The Badimon perfusion chamber is an ex vivo model of thrombosis that assesses the thrombogenicity of blood in humans and large animals. It works with native blood thereby excluding any interfering effects of anticoagulants unavoidable with the majority of platelet function testing methodologies. Each variable of the Virchow’s triad (blood, blood flow, and endothelial wall) that modulates blood–vessel wall interaction and thrombus formation is incorporated in this perfusion model. These features make this device a valuable tool for the assessment of thrombogenic potential of various diseases and also gauging the efficacy of antithrombotic (anticoagulant and antiplatelet) treatments.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages161-171
Number of pages11
DOIs
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
Volume1816
ISSN (Print)1064-3745

Keywords

  • Arterial thrombosis
  • Perfusion
  • Platelets
  • Thrombus
  • Venous thrombosis

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