Bacillus subtilis contains multiple forms of somatostatin-like material

Derek Leroith, William Pickens, Aaron I. Vinik, Joseph Shiloach

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Extracts of B. subtilis contain somatostatin-like immunoactivity (1-20 pg per g wet weight cells). Two major forms were detected, one with reactivity in both N-and C- terminal immunoassays similar to somatostatin-28 and a second form reactive only in the C-terminal specific immunoassay similar to somatostatin-14. Both forms were active in a bioassay and the bioactivity was neutralized in the presence of antibody to the central, biologically active part of somatostatin-14. Preconditioned medium contained no detectable somatostatin whereas conditioned medium had 80-380 pg per liter.

Original languageEnglish
Pages (from-to)713-719
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume127
Issue number3
DOIs
StatePublished - 29 Mar 1985
Externally publishedYes

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