B cells from a patient with chronic lymphocytic leukemia bind to sheep erythrocytes: An immunological analysis

J. D. Beck; B. Koziner; R. Mertelsmann; C. D. Platsoucas; B. Clarkson; R. A. Good

doi:10.1016/0090-1229(80)90207-X

B cells from a patient with chronic lymphocytic leukemia bind to sheep erythrocytes: An immunological analysis

J. D. Beck
, B. Koziner
, R. Mertelsmann
, C. D. Platsoucas
, B. Clarkson
, R. A. Good

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Binding of sheep erythrocytes to chronic lymphocytic leukemia cells with B-cell properties was observed in a patient with chronic lymphocytic leukemia (CLL). Monoclonal surface immunoglobulin on the surface of B cells probably binds sheep erythrocytes through Forssman antigen. The B-cell nature of the CLL cells was confirmed by lack of cytotoxicity of anti-T cell serum for the lymphocytes of this patient, by rosette formation with mouse red blood cells, and by resynthesis of monoclonal surface immunoglobulin after trypsinization.

Original language	English
Pages (from-to)	233-237
Number of pages	5
Journal	Clinical Immunology and Immunopathology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(80)90207-X
State	Published - Jun 1980
Externally published	Yes

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@article{4620fe1787834a04a655bc665021a449,

title = "B cells from a patient with chronic lymphocytic leukemia bind to sheep erythrocytes: An immunological analysis",

abstract = "Binding of sheep erythrocytes to chronic lymphocytic leukemia cells with B-cell properties was observed in a patient with chronic lymphocytic leukemia (CLL). Monoclonal surface immunoglobulin on the surface of B cells probably binds sheep erythrocytes through Forssman antigen. The B-cell nature of the CLL cells was confirmed by lack of cytotoxicity of anti-T cell serum for the lymphocytes of this patient, by rosette formation with mouse red blood cells, and by resynthesis of monoclonal surface immunoglobulin after trypsinization.",

author = "Beck, \{J. D.\} and B. Koziner and R. Mertelsmann and Platsoucas, \{C. D.\} and B. Clarkson and Good, \{R. A.\}",

note = "Funding Information: The authors wish to thank Dr. S. Gupta for his critical and very helpful discussion. We wish to acknowledge the expert technical assistance of Ms. S. Khanna. Ms. S. Garber, Ms. E. Frederick, and Mr. A. Prajapati. Supported in part by Grants CA-08748, CA-08742. CA-17267. CA-23766, CA-17404, AI-11843. NS-11457, CB-84228. from the National Institutes of Health, Grants PTD-95 and CH-151 from the American Cancer Society. the Judith Harris Selig Memorial Fund. the J. M. Foundation. and Fund for the Advanced Study Cancer.",

year = "1980",

month = jun,

doi = "10.1016/0090-1229(80)90207-X",

language = "English",

volume = "16",

pages = "233--237",

journal = "Clinical Immunology and Immunopathology",

issn = "0090-1229",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - B cells from a patient with chronic lymphocytic leukemia bind to sheep erythrocytes

T2 - An immunological analysis

AU - Beck, J. D.

AU - Koziner, B.

AU - Mertelsmann, R.

AU - Platsoucas, C. D.

AU - Clarkson, B.

AU - Good, R. A.

N1 - Funding Information: The authors wish to thank Dr. S. Gupta for his critical and very helpful discussion. We wish to acknowledge the expert technical assistance of Ms. S. Khanna. Ms. S. Garber, Ms. E. Frederick, and Mr. A. Prajapati. Supported in part by Grants CA-08748, CA-08742. CA-17267. CA-23766, CA-17404, AI-11843. NS-11457, CB-84228. from the National Institutes of Health, Grants PTD-95 and CH-151 from the American Cancer Society. the Judith Harris Selig Memorial Fund. the J. M. Foundation. and Fund for the Advanced Study Cancer.

PY - 1980/6

Y1 - 1980/6

N2 - Binding of sheep erythrocytes to chronic lymphocytic leukemia cells with B-cell properties was observed in a patient with chronic lymphocytic leukemia (CLL). Monoclonal surface immunoglobulin on the surface of B cells probably binds sheep erythrocytes through Forssman antigen. The B-cell nature of the CLL cells was confirmed by lack of cytotoxicity of anti-T cell serum for the lymphocytes of this patient, by rosette formation with mouse red blood cells, and by resynthesis of monoclonal surface immunoglobulin after trypsinization.

AB - Binding of sheep erythrocytes to chronic lymphocytic leukemia cells with B-cell properties was observed in a patient with chronic lymphocytic leukemia (CLL). Monoclonal surface immunoglobulin on the surface of B cells probably binds sheep erythrocytes through Forssman antigen. The B-cell nature of the CLL cells was confirmed by lack of cytotoxicity of anti-T cell serum for the lymphocytes of this patient, by rosette formation with mouse red blood cells, and by resynthesis of monoclonal surface immunoglobulin after trypsinization.

UR - https://www.scopus.com/pages/publications/0018828308

U2 - 10.1016/0090-1229(80)90207-X

DO - 10.1016/0090-1229(80)90207-X

M3 - Article

C2 - 6966556

AN - SCOPUS:0018828308

SN - 0090-1229

VL - 16

SP - 233

EP - 237

JO - Clinical Immunology and Immunopathology

JF - Clinical Immunology and Immunopathology

IS - 2

ER -

B cells from a patient with chronic lymphocytic leukemia bind to sheep erythrocytes: An immunological analysis

Abstract

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