B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins

Thibaud T. Renault, Rana Elkholi, Archana Bharti, Jerry E. Chipuk

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Background: BH3 mimetics are promising chemotherapeutics, but their full mechanisms of action are underexplored.

Results: BAX, BID, and BIM directly influence BH3 mimetics to pharmacologically inhibit anti-apoptotic BCL-2 proteins.

Conclusion: BH3 mimetics display differential activities that are dependent upon both anti- and proapoptotic BCL-2 members function.

Significance: Understanding how BH3 mimetics function within the BCL-2 family repertoire will improve the utility of these drugs.

Original languageEnglish
Pages (from-to)26481-26491
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number38
DOIs
StatePublished - 19 Sep 2014

Fingerprint

Dive into the research topics of 'B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins'. Together they form a unique fingerprint.

Cite this