B cell differentiation: Role of E2A and Pax5/BSAP transcription factors

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19 Scopus citations


Transcriptional regulation of lineage specific genes has the ability to dictate both the proliferative and differentiative poteintials of a pluipotent precursor cell. The E2A and Pax5/BSAP genes encode transcription factors which bind to B cell specific promoters and enhancers and guide the development of immature, but committed cells into mature B lymphocytes which express and secrete immunoglobulins. In vitro analysis has consistently suggested that these proteins regulate distinct classes of genes during B cell differentiation; however, recent targeted gene disruption and transgene expression in mice has indicated that these genes may actually be components of a single regulatory mechanism which is essential for both B lymphocyte differentiation and proliferation.

Original languageEnglish
Pages (from-to)413-426
Number of pages14
Issue number3
StatePublished - 1995
Externally publishedYes


  • B cell differentiation
  • BSAP
  • E2A
  • Pax5


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