Azathioprine experience in severe, generalized, recalcitrant myasthenia gravis

P. Kornfeld, E. P. Ambinder, R. Matta, A. Bender, A. E. Papatestas, H. Gross, G. Genkins

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Twenty-one thymectomized patients with severe generalized myasthenia gravis resistant to anticholinesterases, steroids, and plasmapheresis were observed on azathioprine over a 5-year period. Only six patients (29%) seemed to improve clinically, and eight patients (38%) demonstrated significant toxicity to the drug. However, the natural fluctuations in clinical course of myasthenia gravis plus gradual improvement observed postthymectomy can make proper evaluation of additional therapies difficult.

Original languageEnglish
Pages (from-to)347-357
Number of pages11
JournalMount Sinai Journal of Medicine
Issue number5
StatePublished - 1985


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