Axonal damage is a late component of vacuolar myelopathy

Matthew Rottnek, Alessandro Di Rocco, Damien Laudier, Susan Morgello

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The role of axonopathy in myelin disorders recently has been examined. To investigate axonal pathologic changes in vacuolar myelopathy (VM), semiquantitative immunohistochemical stains for inflammation, axonal damage, and gliosis were performed on spinal cord sections from patients with AIDS with and without VM and from HIV-negative controls. Significant axonal damage was present in only moderate to severe VM, despite inflammation at all stages. The authors conclude that axonal damage is not present in early disease; it is present in moderate to severe vacuolar myelopathy and may contribute to clinical deficits in late stages of this disorder.

Original languageEnglish
Pages (from-to)479-481
Number of pages3
JournalNeurology
Volume58
Issue number3
DOIs
StatePublished - 12 Feb 2002

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