Autosomal Dominant Spondyloarthropathy: No Linkage to the Type II Collagen Gene

A. Superti-Furga, B. Steinmann, B. Lee, F. Ramirez, T. Lehner, J. Ott, A. Gaucher, P. Moreau, G. Weryha

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: We have described a large family in which adult-onset seronegative spondylarthropathy was inherited as an autosomal dominant trait (April 6 issue).1 The disease did not segregate with the HLA locus, and the HLA-B27 antigen, a known genetic factor predisposing patients to spondyloarthropathies,2 was not found in any affected family member. Because of recent evidence of genetic linkage between familial osteoarthrosis and the gene of cartilage-specific Type II collagen (COL2A1),3,4 we examined whether markers at the COL2A1 locus segregate with the clinical phenotype in this family. Twenty-six affected and unaffected family members underwent genotyping with the use of.

Original languageEnglish
Pages (from-to)552-553
Number of pages2
JournalNew England Journal of Medicine
Issue number8
StatePublished - 22 Feb 1990


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