Autophagy proteins influence endocytosis for MHC restricted antigen presentation

Christian Münz

doi:10.1016/j.semcancer.2019.03.005

Autophagy proteins influence endocytosis for MHC restricted antigen presentation

Christian Münz

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

T cells of the adaptive immune system monitor protein degradation products via their presentation on major histocompatibility complex (MHC) molecules to recognize infected cells. Both macroautophagy and endocytosis target intra- and extracellular constituents, respectively, for lysosomal degradation. This results in antigen processing for MHC presentation and influences the trafficking of MHC molecules. This review will discuss recent evidence that the molecular machinery of macroautophagy regulates also endocytosis at the level of phagosome maturation and cell membrane internalization. These non-canonical functions of this machinery affect both MHC class I and II restricted antigen presentation to CD8⁺ and CD4⁺ T cells, respectively, and should be harnessed to improve immune responses against infectious diseases and cancer.

Original language	English
Pages (from-to)	110-115
Number of pages	6
Journal	Seminars in Cancer Biology
Volume	66
DOIs	https://doi.org/10.1016/j.semcancer.2019.03.005
State	Published - Nov 2020
Externally published	Yes

Keywords

CD4 T cell stimulation
CD8 T cell responses
LC3 associated phagocytosis (LAP)
MHC class I internalization
MHC class II antigen processing

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10.1016/j.semcancer.2019.03.005

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title = "Autophagy proteins influence endocytosis for MHC restricted antigen presentation",

abstract = "T cells of the adaptive immune system monitor protein degradation products via their presentation on major histocompatibility complex (MHC) molecules to recognize infected cells. Both macroautophagy and endocytosis target intra- and extracellular constituents, respectively, for lysosomal degradation. This results in antigen processing for MHC presentation and influences the trafficking of MHC molecules. This review will discuss recent evidence that the molecular machinery of macroautophagy regulates also endocytosis at the level of phagosome maturation and cell membrane internalization. These non-canonical functions of this machinery affect both MHC class I and II restricted antigen presentation to CD8+ and CD4+ T cells, respectively, and should be harnessed to improve immune responses against infectious diseases and cancer.",

keywords = "CD4 T cell stimulation, CD8 T cell responses, LC3 associated phagocytosis (LAP), MHC class I internalization, MHC class II antigen processing",

author = "Christian M{\"u}nz",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2020",

month = nov,

doi = "10.1016/j.semcancer.2019.03.005",

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volume = "66",

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AU - Münz, Christian

PY - 2020/11

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N2 - T cells of the adaptive immune system monitor protein degradation products via their presentation on major histocompatibility complex (MHC) molecules to recognize infected cells. Both macroautophagy and endocytosis target intra- and extracellular constituents, respectively, for lysosomal degradation. This results in antigen processing for MHC presentation and influences the trafficking of MHC molecules. This review will discuss recent evidence that the molecular machinery of macroautophagy regulates also endocytosis at the level of phagosome maturation and cell membrane internalization. These non-canonical functions of this machinery affect both MHC class I and II restricted antigen presentation to CD8+ and CD4+ T cells, respectively, and should be harnessed to improve immune responses against infectious diseases and cancer.

AB - T cells of the adaptive immune system monitor protein degradation products via their presentation on major histocompatibility complex (MHC) molecules to recognize infected cells. Both macroautophagy and endocytosis target intra- and extracellular constituents, respectively, for lysosomal degradation. This results in antigen processing for MHC presentation and influences the trafficking of MHC molecules. This review will discuss recent evidence that the molecular machinery of macroautophagy regulates also endocytosis at the level of phagosome maturation and cell membrane internalization. These non-canonical functions of this machinery affect both MHC class I and II restricted antigen presentation to CD8+ and CD4+ T cells, respectively, and should be harnessed to improve immune responses against infectious diseases and cancer.

KW - CD4 T cell stimulation

KW - CD8 T cell responses

KW - LC3 associated phagocytosis (LAP)

KW - MHC class I internalization

KW - MHC class II antigen processing

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DO - 10.1016/j.semcancer.2019.03.005

M3 - Review article

C2 - 30928540

AN - SCOPUS:85063626228

SN - 1044-579X

VL - 66

SP - 110

EP - 115

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

Autophagy proteins influence endocytosis for MHC restricted antigen presentation

Abstract

Keywords

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