Autophagy proteins in viral exocytosis and anti-viral immune responses

Christian Münz

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Autophagy-related (Atg) gene-encoded proteins were originally described for their crucial role in macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes. Recently it has become clear that modules of this machinery can also be used to influence endo- and exocytosis. This mini review discusses how these alternative Atg functions support virus replication and viral antigen presentation on major histocompatibility (MHC) class I and II molecules. A better understanding of the modular use of the macroautophagy machinery might enable us to manipulate these alternative functions of Atg proteins during anti-viral therapies and to attenuate virus-induced immune pathologies.

Original languageEnglish
Article number288
JournalViruses
Volume9
Issue number10
DOIs
StatePublished - Oct 2017
Externally publishedYes

Keywords

  • Coxsackie B virus
  • Epstein barr virus
  • LAP (LC3 associated phagocytosis)
  • MHC class I molecules
  • MHC class II molecules
  • Poliovirus
  • Varizella zoster virus

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