Abstract
Autophagy-related (Atg) gene-encoded proteins were originally described for their crucial role in macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes. Recently it has become clear that modules of this machinery can also be used to influence endo- and exocytosis. This mini review discusses how these alternative Atg functions support virus replication and viral antigen presentation on major histocompatibility (MHC) class I and II molecules. A better understanding of the modular use of the macroautophagy machinery might enable us to manipulate these alternative functions of Atg proteins during anti-viral therapies and to attenuate virus-induced immune pathologies.
Original language | English |
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Article number | 288 |
Journal | Viruses |
Volume | 9 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2017 |
Externally published | Yes |
Keywords
- Coxsackie B virus
- Epstein barr virus
- LAP (LC3 associated phagocytosis)
- MHC class I molecules
- MHC class II molecules
- Poliovirus
- Varizella zoster virus