Autophagy in Huntington’s and Parkinson’s diseases: Pathogenic mechanisms and therapeutic potentials

Junghyun Lim, Lauren G. Friedman, Nicole C. Mc Knight, Zhenyu Yue

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Emerging evidence demonstrates the neuroprotective role of autophagy in protein quality and cellular organelle damage control. The interference of genetic mutations and environmental toxins with basal autophagic activity in neurons is detrimental and restoring or enhancing neuronal autophagy in the context of some neurodegenerative diseases is believed to offer protection. This chapter will highlight recent research progress in understanding how autophagy is involved in the pathogenesis of Huntington’s and Parkinson’s diseases as well as the increasing evidence for autophagy as an attractive drug target for these two neurodegenerative disorders.

Original languageEnglish
Title of host publicationAutophagy of the Nervous System
Subtitle of host publicationCellular Self-Digestion in Neurons and Neurological Diseases
PublisherWorld Scientific Publishing Co.
Pages259-284
Number of pages26
ISBN (Electronic)9789814350457
ISBN (Print)9789814350440
DOIs
StatePublished - 1 Jan 2012

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