Emerging evidence demonstrates the neuroprotective role of autophagy in protein quality and cellular organelle damage control. The interference of genetic mutations and environmental toxins with basal autophagic activity in neurons is detrimental and restoring or enhancing neuronal autophagy in the context of some neurodegenerative diseases is believed to offer protection. This chapter will highlight recent research progress in understanding how autophagy is involved in the pathogenesis of Huntington’s and Parkinson’s diseases as well as the increasing evidence for autophagy as an attractive drug target for these two neurodegenerative disorders.
|Title of host publication||Autophagy of the Nervous System|
|Subtitle of host publication||Cellular Self-Digestion in Neurons and Neurological Diseases|
|Publisher||World Scientific Publishing Co.|
|Number of pages||26|
|State||Published - 1 Jan 2012|