Autophagy in Autoimmunity

Jan Lünemann, Christian Münz

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Macroautophagy, a homeostatic process that shuttles cytoplasmic constituents into endosomal and lysosomal compartments, delivers antigens for presentation on major histocompatibility complex (MHC) molecules. Autophagy-mediated antigen processing in thymic epithelial cells has been suggested to be involved in the generation of a self-MHC restricted and self-tolerant CD4+ T cell repertoire. Although autophagy was initially described to deliver intracellular antigens to MHC class II loading compartments, its molecular machinery has now also been described to enhance the delivery of extracellular antigens. This review describes the mechanisms by which the immune system utilizes autophagy to shape and regulate CD4+ T cell responses during tolerance induction and following immune activation.

Original languageEnglish
Title of host publicationThe Autoimmune Diseases
Subtitle of host publicationFifth Edition
PublisherElsevier Inc.
Number of pages6
ISBN (Print)9780123849298
StatePublished - Dec 2013
Externally publishedYes


  • Antigen presentation
  • Autoimmunity
  • Autophagy
  • T cell


Dive into the research topics of 'Autophagy in Autoimmunity'. Together they form a unique fingerprint.

Cite this