Autophagy and Reactive Oxygen Species in Cancer: An Introduction

Paarth Kumar, Chanda Ruchitha, A. Gowtham, Ravinder K. Kaundal

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Autophagy is a fundamental process that plays a critical role in maintaining cellular homeostasis by orchestrating the degradation and recycling of damaged organelles and proteins. ROS are vital in various cellular processes, including proliferation, differentiation, and apoptosis. In cancer, dysregulated autophagy and aberrant ROS levels have become crucial factors influencing tumorigenesis and progression. This book chapter explores the intricate relationship between autophagy and ROS in cancer biology. It begins by explaining the mechanistic underpinnings of autophagy, detailing its regulatory pathways and physiological significance. Additionally, it examines the diverse sources of ROS within the cellular environment and their implications for cancer development. Furthermore, it delves into the intertwined pathways linking autophagy and ROS in cancer. It explores pathways that intricately connect autophagy and ROS in the context of cancer pathogenesis, shedding light on potential therapeutic targets and biomarkers.

Original languageEnglish
Title of host publicationCancer Drug Discovery and Development
PublisherHumana Press Inc.
Pages1-25
Number of pages25
DOIs
StatePublished - 2024
Externally publishedYes

Publication series

NameCancer Drug Discovery and Development
VolumePart F3378
ISSN (Print)2196-9906
ISSN (Electronic)2196-9914

Keywords

  • Autophagy
  • Cancer
  • Mechanism
  • Oxidative stress
  • ROS

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