Automated machine learning-based radiomics analysis versus deep learning-based classification for thyroid nodule on ultrasound images: a multi-center study

Zelong Liu, Louisa Deyer, Arnold Yang, Steven Liu, Jingqi Gong, Yang Yang, Mingqian Huang, Amish Doshi, Meng Lu, Denise Lee, Timothy Deyer, Xueyan Mei

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Often, the characteristics of thyroid nodules need to be determined by fine needle aspiration (FNA) biopsy. The increasing applications of machine learning and deep learning algorithms provide alternative noninvasive methods to study thyroid nodules on ultrasound images. Many studies examined the feasibility of convolutional neural networks or radiomics feature extraction to analyze the characteristics of thyroid nodules. In this study, we built an automated radiomics analysis system by combining thyroid segmentation via U-Net and radiomics feature extraction. Our proposed machine learning-based automated radiomics analysis was compared to a deep learning-based convolutional neural network method in a two-center thyroid nodule classification task. It is shown that the automated radiomics analysis can accurately segment thyroid nodules to facilitate clinical diagnosis by achieving dice scores of 0.77 and 0.74 on internal and external sets respectively. In addition, the proposed automated radiomics analysis approach can improve sensitivity, negative predictive value (NPV) and positive predictive value (PPV) by 41.2%, 3.5% and 7.5% respectively, while reducing the false negative rate by 41.1%.

Original languageEnglish
Title of host publicationProceedings - IEEE 22nd International Conference on Bioinformatics and Bioengineering, BIBE 2022
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages23-28
Number of pages6
ISBN (Electronic)9781665484879
DOIs
StatePublished - 2022
Event22nd IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2022 - Virtual, Online, Taiwan, Province of China
Duration: 7 Nov 20229 Nov 2022

Publication series

NameProceedings - IEEE 22nd International Conference on Bioinformatics and Bioengineering, BIBE 2022

Conference

Conference22nd IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2022
Country/TerritoryTaiwan, Province of China
CityVirtual, Online
Period7/11/229/11/22

Keywords

  • deep learning
  • radimagenet
  • radiomics
  • thyroid nodule
  • ultrasound

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