@inbook{b60c31a7d7a4472ea5c955f17a999c6a,
title = "Automated Detection of Psychedelic-Induced Head-Twitch Response in Mice",
abstract = "Head-twitch response (HTR) allows for the detection and classification of behavior associated with serotonin 2A receptor (5-HT2AR) activation upon psychedelic administration in rodent models. This activation and functional output can be utilized to provide insights into molecular mechanisms associated with psychosis and to identify signaling processes related to existing and novel antipsychotic and psychedelic compounds. Here we describe the use of a magnetic ear tag reporter coupled with automated quantification and biphasic detection to identify HTR in mice treated with the classical psychedelic 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI).",
keywords = "Behavioral model, Hallucinogen, Head-twitch response (HTR), Preclinical, Psychedelics, Psychosis, Rodent models, Schizophrenia, Serotonin 2A receptor (5-HTR)",
author = "Jaster, {Alaina M.} and Javier Gonz{\'a}lez-Maeso",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2023",
doi = "10.1007/978-1-0716-3307-6_6",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "65--76",
booktitle = "Methods in Molecular Biology",
}