TY - JOUR
T1 - Autologous stem cell transplantation as a care option in Waldenström's macroglobulinemia
AU - Usmani, Saad
AU - Sexton, Rachel
AU - Crowley, John
AU - Barlogie, Bart
PY - 2011/2/1
Y1 - 2011/2/1
N2 - The optimal management of Waldenstrom's macroglobulinemia (WM) is in evolution, especially since the introduction of novel agents for its sister disease, multiple myeloma. Literature on the utility of autologous stem cell transplantation (ASCT) in WM, albeit mostly retrospective, supports its efficacy for symptomatic disease in eligible patients. Here, we present the experience of managing WM at our single institution. We report that ASCT improved OS/EFS in both treatment-naive and previously treated WM patients. Elevated LDH emerged as a poor prognostic factor in both univariate and multivariate analyses. Based on these data and other series of autologous SCT experience, it may be feasible to employ this strategy upfront in transplant eligible WM patients when they require a therapeutic intervention for symptomatic disease.
AB - The optimal management of Waldenstrom's macroglobulinemia (WM) is in evolution, especially since the introduction of novel agents for its sister disease, multiple myeloma. Literature on the utility of autologous stem cell transplantation (ASCT) in WM, albeit mostly retrospective, supports its efficacy for symptomatic disease in eligible patients. Here, we present the experience of managing WM at our single institution. We report that ASCT improved OS/EFS in both treatment-naive and previously treated WM patients. Elevated LDH emerged as a poor prognostic factor in both univariate and multivariate analyses. Based on these data and other series of autologous SCT experience, it may be feasible to employ this strategy upfront in transplant eligible WM patients when they require a therapeutic intervention for symptomatic disease.
UR - http://www.scopus.com/inward/record.url?scp=79953723177&partnerID=8YFLogxK
U2 - 10.3816/CLML.2011.n.032
DO - 10.3816/CLML.2011.n.032
M3 - Article
C2 - 21454216
AN - SCOPUS:79953723177
SN - 2152-2650
VL - 11
SP - 139
EP - 142
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 1
ER -