Autologous stem cell transplantation as a care option in Waldenström's macroglobulinemia

Saad Usmani, Rachel Sexton, John Crowley, Bart Barlogie

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The optimal management of Waldenstrom's macroglobulinemia (WM) is in evolution, especially since the introduction of novel agents for its sister disease, multiple myeloma. Literature on the utility of autologous stem cell transplantation (ASCT) in WM, albeit mostly retrospective, supports its efficacy for symptomatic disease in eligible patients. Here, we present the experience of managing WM at our single institution. We report that ASCT improved OS/EFS in both treatment-naive and previously treated WM patients. Elevated LDH emerged as a poor prognostic factor in both univariate and multivariate analyses. Based on these data and other series of autologous SCT experience, it may be feasible to employ this strategy upfront in transplant eligible WM patients when they require a therapeutic intervention for symptomatic disease.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalClinical Lymphoma, Myeloma and Leukemia
Volume11
Issue number1
DOIs
StatePublished - 1 Feb 2011
Externally publishedYes

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