Autologous and allogeneic red cell survival studies in the presence of autoanti‐AnWj

C. F. Whitsett, V. W. Hare, S. M. Oxendine, J. A. Pierce

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Chromium survival studies were performed with AnWj‐positive allogeneic blood in a patient with autoanti‐AnWj. 99mTc‐labeled autologous RBCs that had depressed AnWj expression had normal survival (77% [94.7% 51Cr equivalent]) at 24 hours, whereas 51Cr‐labeled allogeneic AnWj‐positive cells had 76 percent survival at 24 hours and 55 percent survival at 7 days. These studies suggest that the specificity of the autoantibody may have implications for transfusion therapy when the development of such autoantibodies is associated with decreased antigen expression on the patient's cells. 1993 AABB

Original languageEnglish
Pages (from-to)845-847
Number of pages3
JournalTransfusion
Volume33
Issue number10
DOIs
StatePublished - Oct 1993
Externally publishedYes

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