AUTOFLUORESCENT TIMELINE of SPOTS and DOTS in MULTIPLE EVANESCENT WHITE DOT SYNDROME

Jackson M. Scharf, Assaf Hilely, K. Bailey Freund, David Sarraf

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Purpose:To describe the recovery timeline of spots and dots in multiple evanescent white dot syndrome.Methods:Sequential multimodal retinal imaging including fundus autofluorescence and cross-sectional and en face optical coherence tomography was performed to track the development and resolution of spots and dots in a case of multiple evanescent white dot syndrome.Results:En face optical coherence tomography showed that the spots are the result of ellipsoid zone loss and are hyperautofluorescent due to unmasking of the underlying retinal pigment epithelium autofluorescence. Conversely, the dots are hyperreflective with cross-sectional and en face optical coherence tomography and hyperautofluorescent, which we propose may be due to accumulation of degenerated photoreceptor material including fluorophores with autofluorescent capability such as precursors of A2E. The earlier resolution of the hyperautofluorescent spots allowed for later detection of the hyperautofluorescent dots.Conclusion:This case report illustrates the different recovery timelines of spots and dots in multiple evanescent white dot syndrome. Although both lesion types are hyperautofluorescent, the mechanism of autofluorescence is distinctive and may be explained by their contrasting pathoanatomy.

Original languageEnglish
Pages (from-to)280-284
Number of pages5
JournalRetinal Cases and Brief Reports
Volume16
Issue number3
DOIs
StatePublished - 1 May 2022
Externally publishedYes

Keywords

  • MEWDS
  • OCT
  • autofluorescence
  • ophthalmology
  • retina
  • white dot syndromes

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