Autocrine and paracrine effects of a novel podocyte gene, RARRES1

Anqun Chen; Kyung Lee; John Cijiang He

doi:10.1016/j.kint.2021.07.008

Autocrine and paracrine effects of a novel podocyte gene, RARRES1

Anqun Chen, Kyung Lee, John Cijiang He

Research output: Contribution to journal › Comment/debate

8 Scopus citations

Abstract

Retinoic acid receptor responder protein 1 (RARRES1) has been identified as a novel gene for the regulation of podocyte function, and its expression is increased in glomerular disease and associated with disease progression. Increased expression of RARRES1 in podocytes leads to apoptosis through an autocrine effect. Möller-Hackbarth et al. recently found that RARRES1 expression is increased in the endothelial cells in some diseased kidneys to promote podocyte injury, likely through a paracrine effect.

Original language	English
Pages (from-to)	745-747
Number of pages	3
Journal	Kidney International
Volume	100
Issue number	4
DOIs	https://doi.org/10.1016/j.kint.2021.07.008
State	Published - Oct 2021

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title = "Autocrine and paracrine effects of a novel podocyte gene, RARRES1",

abstract = "Retinoic acid receptor responder protein 1 (RARRES1) has been identified as a novel gene for the regulation of podocyte function, and its expression is increased in glomerular disease and associated with disease progression. Increased expression of RARRES1 in podocytes leads to apoptosis through an autocrine effect. M{\"o}ller-Hackbarth et al. recently found that RARRES1 expression is increased in the endothelial cells in some diseased kidneys to promote podocyte injury, likely through a paracrine effect.",

author = "Anqun Chen and Kyung Lee and He, {John Cijiang}",

note = "Publisher Copyright: {\textcopyright} 2021 International Society of Nephrology",

year = "2021",

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AU - Chen, Anqun

AU - Lee, Kyung

AU - He, John Cijiang

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N2 - Retinoic acid receptor responder protein 1 (RARRES1) has been identified as a novel gene for the regulation of podocyte function, and its expression is increased in glomerular disease and associated with disease progression. Increased expression of RARRES1 in podocytes leads to apoptosis through an autocrine effect. Möller-Hackbarth et al. recently found that RARRES1 expression is increased in the endothelial cells in some diseased kidneys to promote podocyte injury, likely through a paracrine effect.

AB - Retinoic acid receptor responder protein 1 (RARRES1) has been identified as a novel gene for the regulation of podocyte function, and its expression is increased in glomerular disease and associated with disease progression. Increased expression of RARRES1 in podocytes leads to apoptosis through an autocrine effect. Möller-Hackbarth et al. recently found that RARRES1 expression is increased in the endothelial cells in some diseased kidneys to promote podocyte injury, likely through a paracrine effect.

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DO - 10.1016/j.kint.2021.07.008

M3 - Comment/debate

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SN - 0085-2538

VL - 100

SP - 745

EP - 747

JO - Kidney International

JF - Kidney International

IS - 4

ER -

Autocrine and paracrine effects of a novel podocyte gene, RARRES1

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