@inbook{8080651fb3744df7b1010f35f56f38c5,
title = "Autoantibodies against cancer antigens",
abstract = "With the identification of tumor antigens, the host immune response to various types of cancers can now be studied with a high degree of specificity in large cohorts of patients, in the hope of correlating immunity with clinical events and defining immunotherapeutic strategies. Several antigens, such as NY-ESO-1, p53, or SOX2, have attracted attention because of their frequent spontaneous immunogenicity in cancer patients, notably in their ability to induce humoral responses. We describe in this chapter a simple implementation of a serological monitoring platform for autoantibody measurement in cancer patients, from production of recombinant antigens to ELISA testing and interpretation.",
keywords = "Antibody titration and titer calculation, Enzyme-linked immunosorbent assay, Humoral immunity, Immunoediting, Immunoglobulin (IgG, IgM, IgG1, IgG2, IgG3, IgG4), Immunosurveillance, Plasma, Protein purification, Serological screening, Serum, Tumor antigen",
author = "Sacha Gnjatic and Old, \{Lloyd J.\} and Chen, \{Yao Tseng\}",
year = "2009",
doi = "10.1007/978-1-60327-811-9\_2",
language = "English",
isbn = "9781603278102",
series = "Methods in Molecular Biology",
pages = "11--19",
editor = "Michael Tainsky",
booktitle = "Tumor Biomarker Discovery",
}