TY - JOUR
T1 - Autism Spectrum Disorder and Epilepsy
AU - Kwon, Churl Su
AU - Wirrell, Elaine C.
AU - Jetté, Nathalie
N1 - Funding Information:
Churl-Su Kwon has no relevant disclosures. Nathalie Jette receives grant funding paid to her institution for grants unrelated to this work from NINDS ( NIH U24NS107201 , NIH IU54NS100064 ). She is the Bludhorn Professor of International Medicine. She receives an honorarium for her work as an Associate Editor of Epilepsia. Elaine C Wirrell has served as a paid consultant for Encoded Therapeutics and BioMarin. She is the Editor-in-Chief of Epilepsy.com .
PY - 2022/11
Y1 - 2022/11
N2 - Autism spectrum disorder (ASD), was first described in 1943 as a disorder consisting of a triad of qualitative impairments of social interaction, communication and restricted repetitive patterns of behavior, interests, and activities. The relationship between ASD and epilepsy is well documented. Patients with ASD have an increased risk of epilepsy, while those with epilepsy have a higher risk of ASD, as compared with the general population. Diagnosing epilepsy in those with ASD can be challenging. For example, stereotyped behaviors could be mistaken as ASD stereotypies, when in fact, they may be due to seizures. Fortunately, in recent years, we have gained a better understanding of the best antiseizure medications (ASMs) to use in this vulnerable population. However, more studies are needed to understand how best to screen for ASD in epilepsy, what the various ASD phenotypes are in people with epilepsy, especially those due to de novo genes/mutations, as well as factors influencing the fluctuating nature of ASD symptoms (eg, seizure type, frequency, syndromes, ASMs)..
AB - Autism spectrum disorder (ASD), was first described in 1943 as a disorder consisting of a triad of qualitative impairments of social interaction, communication and restricted repetitive patterns of behavior, interests, and activities. The relationship between ASD and epilepsy is well documented. Patients with ASD have an increased risk of epilepsy, while those with epilepsy have a higher risk of ASD, as compared with the general population. Diagnosing epilepsy in those with ASD can be challenging. For example, stereotyped behaviors could be mistaken as ASD stereotypies, when in fact, they may be due to seizures. Fortunately, in recent years, we have gained a better understanding of the best antiseizure medications (ASMs) to use in this vulnerable population. However, more studies are needed to understand how best to screen for ASD in epilepsy, what the various ASD phenotypes are in people with epilepsy, especially those due to de novo genes/mutations, as well as factors influencing the fluctuating nature of ASD symptoms (eg, seizure type, frequency, syndromes, ASMs)..
KW - ASD
KW - Antiseizure medications
KW - Epilepsy surgery
KW - Genetic
KW - Neuromodulation
KW - Seizures
UR - http://www.scopus.com/inward/record.url?scp=85140353060&partnerID=8YFLogxK
U2 - 10.1016/j.ncl.2022.03.011
DO - 10.1016/j.ncl.2022.03.011
M3 - Review article
C2 - 36270694
AN - SCOPUS:85140353060
SN - 0733-8619
VL - 40
SP - 831
EP - 847
JO - Neurologic Clinics
JF - Neurologic Clinics
IS - 4
ER -