TY - JOUR
T1 - Atypical neural substrates of Embedded Figures Task performance in children with Autism Spectrum Disorder
AU - Lee, Philip S.
AU - Foss-Feig, Jennifer
AU - Henderson, Joshua G.
AU - Kenworthy, Lauren E.
AU - Gilotty, Lisa
AU - Gaillard, William D.
AU - Vaidya, Chandan J.
N1 - Funding Information:
This research study was funded in part by a grant from the Frederick and Elizabeth Singer Foundation to Children’s National Medical Center, a grant from the National Alliance for Autism Research to CJV, and a General Clinical Research Center grant from the National Institutes of Health to Children’s National Medical Center (MO1-RR020359-03). Special thanks to John VanMeter, Laura Girton, Anna Scozzofava, and Lauren Kaplan for technical assistance and imaging data collection and to Antoinette Della Rosa, Joette James and Sara McCracken for diagnostic and cognitive testing. Jennifer Foss-Feig is now at the Department of Psychology and Human Development, Vanderbilt University. Lisa Gilotty completed portions of this work while at the Center for Autism Spectrum Disorders, Children’s National Medical Center. Preliminary analysis of these data was presented at the 2006 Annual Meeting of the Society for Neuroscience in Atlanta, Georgia.
PY - 2007/10/15
Y1 - 2007/10/15
N2 - Superior performance on the Embedded Figures Task (EFT) has been attributed to weak central coherence in perceptual processing in Autism Spectrum Disorder (ASD). The present study used functional magnetic resonance imaging to examine the neural basis of EFT performance in 7- to 12-year-old ASD children and age- and IQ-matched controls. ASD children activated only a subset of the distributed network of regions activated in controls. In frontal cortex, control children activated left dorsolateral, medial and dorsal premotor regions whereas ASD children only activated the dorsal premotor region. In parietal and occipital cortices, activation was bilateral in control children but unilateral (left superior parietal and right occipital) in ASD children. Further, extensive bilateral ventral temporal activation was observed in control, but not ASD children. ASD children performed the EFT at the same level as controls but with reduced cortical involvement, suggesting that disembedded visual processing is accomplished parsimoniously by ASD relative to typically developing brains.
AB - Superior performance on the Embedded Figures Task (EFT) has been attributed to weak central coherence in perceptual processing in Autism Spectrum Disorder (ASD). The present study used functional magnetic resonance imaging to examine the neural basis of EFT performance in 7- to 12-year-old ASD children and age- and IQ-matched controls. ASD children activated only a subset of the distributed network of regions activated in controls. In frontal cortex, control children activated left dorsolateral, medial and dorsal premotor regions whereas ASD children only activated the dorsal premotor region. In parietal and occipital cortices, activation was bilateral in control children but unilateral (left superior parietal and right occipital) in ASD children. Further, extensive bilateral ventral temporal activation was observed in control, but not ASD children. ASD children performed the EFT at the same level as controls but with reduced cortical involvement, suggesting that disembedded visual processing is accomplished parsimoniously by ASD relative to typically developing brains.
UR - https://www.scopus.com/pages/publications/34548757333
U2 - 10.1016/j.neuroimage.2007.07.013
DO - 10.1016/j.neuroimage.2007.07.013
M3 - Article
C2 - 17707658
AN - SCOPUS:34548757333
SN - 1053-8119
VL - 38
SP - 184
EP - 193
JO - NeuroImage
JF - NeuroImage
IS - 1
ER -