Atypical dental implant failure with long-term bisphosphonate treatment - Akin to atypical fractures?

Gayathri Subramanian, J. Christopher Fritton, Shankar Iyer, Samuel Y.P. Quek

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Concern that long-term bisphosphonate therapy may significantly undermine bone quality in osteoporotic patients has been heightened by rare instances of low-impact atypical femoral fractures that are often bilateral. Reduced fracture toughness is believed to result from reduced bone remodeling, leading to increased homogeneity in bone microarchitecture, narrowed bone mineral density distribution, and increased bone tissue microdamage burden. We postulate that these long-term alterations in bone quality may undermine the ongoing remodeling surrounding osteointegrated endosseous dental implants as well. To illustrate our hypothesis, we report the catastrophic failure of multiple, successfully osteointegrated dental implants in an osteopenic patient following long-term bisphosphonate treatment. This clinical presentation may reflect underlying adverse changes in bone quality, in a manner analogous to atypical fractures in a small percentage of patients on bisphosphonates. This report highlights the need for multidisciplinary care of patients who have dental implants and begin or are receiving long-term bisphosphonate therapy.

Original languageEnglish
Pages (from-to)e30-e35
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Issue number6
StatePublished - Dec 2012
Externally publishedYes


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