TY - JOUR
T1 - Atrial natriuretic factor in normal and hypertensive pregnancy
AU - Bond, Annette L.
AU - August, Phyllis
AU - Druzin, Maurice L.
AU - Atlas, Steven A.
AU - Sealey, Jean E.
AU - Laragh, John H.
N1 - Funding Information:
From the Department of Obstetncs and Gynecology and the Cardio-vascular Center, New York Hospital-Cornell MedIcal Center. Supported by a National Institutes of Health Grant, Hypertension SCOR HL-18323-SCR. Received for publicatIOn September 11, 1988; accepted December 5, 1988. Reprint requests: Annette Bond, MD, Department of ObstetriCs and Gynecology, New York HospItal-Cornell Medical Center, 525 E. 68th St., Room M-036, New York, NY 10021.
PY - 1989/5
Y1 - 1989/5
N2 - Atrial natriuretic factor may play a role in the regulation of blood pressure, renal function, and volume homeostasis in normal and pathologic states. Atrial natriuretic factor and plasma renin activity were measured by radioimmunoassay in pregnant women with normal blood pressure (n = 29), chronic hypertension (n = 17), and preeclampsia (n = 18) during the first, second, and third trimesters and in the postpartum period. Serial data were obtained in 11 patients. Nonpregnant age-matched women were used as controls (n = 14). In normal gestation and in chronic hypertension, atrial natriuretic factor levels were in the same range as that in the control group. Mean atrial natriuretic factor was significantly higher in the antepartum and postpartum periods in severe preeclampsia. There was an inverse relationship between atrial natriuretic factor and plasma renin activity in pregnancies complicated by chronic hypertension or preeclampsia. Although fluctuations in atrial natriuretic factor levels did not predict preeclampsia, atrial natriuretic factor did correlate with the severity of the disease.
AB - Atrial natriuretic factor may play a role in the regulation of blood pressure, renal function, and volume homeostasis in normal and pathologic states. Atrial natriuretic factor and plasma renin activity were measured by radioimmunoassay in pregnant women with normal blood pressure (n = 29), chronic hypertension (n = 17), and preeclampsia (n = 18) during the first, second, and third trimesters and in the postpartum period. Serial data were obtained in 11 patients. Nonpregnant age-matched women were used as controls (n = 14). In normal gestation and in chronic hypertension, atrial natriuretic factor levels were in the same range as that in the control group. Mean atrial natriuretic factor was significantly higher in the antepartum and postpartum periods in severe preeclampsia. There was an inverse relationship between atrial natriuretic factor and plasma renin activity in pregnancies complicated by chronic hypertension or preeclampsia. Although fluctuations in atrial natriuretic factor levels did not predict preeclampsia, atrial natriuretic factor did correlate with the severity of the disease.
KW - Atrial natriuretic factor
KW - chronic hypertension
KW - plasma renin activity
KW - pregnancy-induced hypertension
UR - http://www.scopus.com/inward/record.url?scp=0024399140&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(89)90171-3
DO - 10.1016/0002-9378(89)90171-3
M3 - Article
C2 - 2524972
AN - SCOPUS:0024399140
SN - 0002-9378
VL - 160
SP - 1112
EP - 1116
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 5 PART 1
ER -