Atrial Fibrillation in Patients Hospitalized With COVID-19: Incidence, Predictors, Outcomes, and Comparison to Influenza

Daniel R. Musikantow, Mohit K. Turagam, Samantha Sartori, Edward Chu, Iwanari Kawamura, Poojita Shivamurthy, Mahmoud Bokhari, Connor Oates, Chi Zhang, Christopher Pumill, Waqas Malick, Helen Hashemi, Tania Ruiz-Maya, Michael B. Hadley, Jonathan Gandhi, Dylan Sperling, William Whang, Jacob S. Koruth, Marie Noelle Langan, Aamir SofiAnthony Gomes, Stephanie Harcum, Sam Cammack, Betsy Ellsworth, Srinivas R. Dukkipati, Adel Bassily-Marcus, Roopa Kohli-Seth, Martin E. Goldman, Jonathan L. Halperin, Valentin Fuster, Vivek Y. Reddy

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Objectives: The goal of this study is to determine the incidence, predictors, and outcomes of atrial fibrillation (AF) or atrial flutter (AFL) in patients hospitalized with coronavirus disease-2019 (COVID-19). Background: COVID-19 results in increased inflammatory markers previously associated with atrial arrhythmias. However, little is known about their incidence or specificity in COVID-19 or their association with outcomes. Methods: This is a retrospective analysis of 3,970 patients admitted with polymerase chain reaction–positive COVID-19 between February 4 and April 22, 2020, with manual review performed of 1,110. The comparator arm included 1,420 patients with influenza hospitalized between January 1, 2017, and January 1, 2020. Results: Among 3,970 inpatients with COVID-19, the incidence of AF/AFL was 10% (n = 375) and in patients without a history of atrial arrhythmias it was 4% (n = 146). Patients with new-onset AF/AFL were older with increased inflammatory markers including interleukin 6 (93 vs. 68 pg/ml; p < 0.01), and more myocardial injury (troponin-I: 0.2 vs. 0.06 ng/ml; p < 0.01). AF and AFL were associated with increased mortality (46% vs. 26%; p < 0.01). Manual review captured a somewhat higher incidence of AF/AFL (13%, n = 140). Compared to inpatients with COVID-19, patients with influenza (n = 1,420) had similar rates of AF/AFL (12%, n = 163) but lower mortality. The presence of AF/AFL correlated with similarly increased mortality in both COVID-19 (relative risk: 1.77) and influenza (relative risk: 1.78). Conclusions: AF/AFL occurs in a subset of patients hospitalized with either COVID-19 or influenza and is associated with inflammation and disease severity in both infections. The incidence and associated increase in mortality in both cohorts suggests that AF/AFL is not specific to COVID-19, but is rather a generalized response to the systemic inflammation of severe viral illnesses.

Original languageEnglish
Pages (from-to)1120-1130
Number of pages11
JournalJACC: Clinical Electrophysiology
Volume7
Issue number9
DOIs
StatePublished - Sep 2021

Keywords

  • atrial fibrillation
  • atrial flutter
  • coronavirus disease-2019
  • influenza
  • ischemic stroke

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