Atopic Dermatitis: Update on Pathogenesis and Comorbidities

Jonathan I. Silverberg, Nanette B. Silverberg

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Atopic dermatitis (AD) is a significant cause of morbidity and healthcare costs in the United States and worldwide. The prevalence of AD in childhood is rising in the United States and other developed countries for reasons that are not well understood. Similarly, the prevalences of obesity and diabetes are on the rise, which might be contributing toward increased AD. This article reviews the association between AD and other atopic disorders with obesity and diabetes. Furthermore, recently recognized AD comorbidities, including fatty liver disease and erectile dysfunction, are reviewed. Potential mechanisms for the association between AD and metabolic disorders are discussed.

Original languageEnglish
Pages (from-to)168-178
Number of pages11
JournalCurrent Dermatology Reports
Issue number4
StatePublished - Dec 2012
Externally publishedYes


  • Asthma
  • Atopic dermatitis
  • Atopy
  • Comorbidities
  • Cutaneous infections
  • Diabetes
  • Eczema
  • Erectile dysfunction
  • Fatty liver
  • Filaggrin
  • Food allergies
  • Hand dermatitis
  • IgE
  • Innate immune system
  • Obesity
  • Rhinoconjunctivitis


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