Atomoxetine treatment of ADHD in children with comorbid tourette syndrome

Thomas J. Spencer; F. Randy Sallee; Donald L. Gilbert; David W. Dunn; James T. McCracken; Barbara J. Coffey; Cathy L. Budman; Randall K. Ricardi; Henrietta L. Leonard; Albert J. Allen; Denai R. Milton; Peter D. Feldman; Douglas K. Kelsey; Daniel A. Geller; Steven L. Linder; Donald W. Lewis; Paul K. Winner; Roger M. Kurlan; Mark Mintz

doi:10.1177/1087054707306109

Atomoxetine treatment of ADHD in children with comorbid tourette syndrome

Thomas J. Spencer, F. Randy Sallee, Donald L. Gilbert, David W. Dunn, James T. McCracken, Barbara J. Coffey, Cathy L. Budman, Randall K. Ricardi, Henrietta L. Leonard, Albert J. Allen, Denai R. Milton, Peter D. Feldman, Douglas K. Kelsey, Daniel A. Geller, Steven L. Linder, Donald W. Lewis, Paul K. Winner, Roger M. Kurlan, Mark Mintz

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Objective: This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS). Method: Subjects (7-17 years old) with ADHD (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV) and TS were randomly assigned to double-blind treatment with placebo (n = 56) or atomoxetine (0.5-1.5 mg/kg/day, n = 61) for approximately 18 weeks. Results: Atomoxetine subjects showed significantly greater improvement on ADHD symptom measures. Treatment was also associated with significantly greater reduction of tic severity on two of three measures. Significant increases were seen in mean pulse rate and rates of treatment-emergent nausea, decreased appetite, and decreased body weight. No other clinically relevant treatment differences were observed in any other vital sign, adverse event, laboratory parameter, or electrocardiographic measure. Conclusion: Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS. (J. of Att. Dis. 2008; 11(4) 470-481).

Original language	English
Pages (from-to)	470-481
Number of pages	12
Journal	Journal of Attention Disorders
Volume	11
Issue number	4
DOIs	https://doi.org/10.1177/1087054707306109
State	Published - Jan 2008
Externally published	Yes

Keywords

ADHD
Atomoxetine
Tic disorders
Tourette syndrome

Access to Document

10.1177/1087054707306109

Cite this

Spencer, T. J., Sallee, F. R., Gilbert, D. L., Dunn, D. W., McCracken, J. T., Coffey, B. J., Budman, C. L., Ricardi, R. K., Leonard, H. L., Allen, A. J., Milton, D. R., Feldman, P. D., Kelsey, D. K., Geller, D. A., Linder, S. L., Lewis, D. W., Winner, P. K., Kurlan, R. M., & Mintz, M. (2008). Atomoxetine treatment of ADHD in children with comorbid tourette syndrome. Journal of Attention Disorders, 11(4), 470-481. https://doi.org/10.1177/1087054707306109

@article{21ac106304f74f01a38c7605032bb003,

title = "Atomoxetine treatment of ADHD in children with comorbid tourette syndrome",

abstract = "Objective: This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS). Method: Subjects (7-17 years old) with ADHD (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV) and TS were randomly assigned to double-blind treatment with placebo (n = 56) or atomoxetine (0.5-1.5 mg/kg/day, n = 61) for approximately 18 weeks. Results: Atomoxetine subjects showed significantly greater improvement on ADHD symptom measures. Treatment was also associated with significantly greater reduction of tic severity on two of three measures. Significant increases were seen in mean pulse rate and rates of treatment-emergent nausea, decreased appetite, and decreased body weight. No other clinically relevant treatment differences were observed in any other vital sign, adverse event, laboratory parameter, or electrocardiographic measure. Conclusion: Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS. (J. of Att. Dis. 2008; 11(4) 470-481).",

keywords = "ADHD, Atomoxetine, Tic disorders, Tourette syndrome",

author = "Spencer, {Thomas J.} and Sallee, {F. Randy} and Gilbert, {Donald L.} and Dunn, {David W.} and McCracken, {James T.} and Coffey, {Barbara J.} and Budman, {Cathy L.} and Ricardi, {Randall K.} and Leonard, {Henrietta L.} and Allen, {Albert J.} and Milton, {Denai R.} and Feldman, {Peter D.} and Kelsey, {Douglas K.} and Geller, {Daniel A.} and Linder, {Steven L.} and Lewis, {Donald W.} and Winner, {Paul K.} and Kurlan, {Roger M.} and Mark Mintz",

year = "2008",

month = jan,

doi = "10.1177/1087054707306109",

language = "English",

volume = "11",

pages = "470--481",

journal = "Journal of Attention Disorders",

issn = "1087-0547",

publisher = "SAGE Publications Inc.",

number = "4",

}

Spencer, TJ, Sallee, FR, Gilbert, DL, Dunn, DW, McCracken, JT, Coffey, BJ, Budman, CL, Ricardi, RK, Leonard, HL, Allen, AJ, Milton, DR, Feldman, PD, Kelsey, DK, Geller, DA, Linder, SL, Lewis, DW, Winner, PK, Kurlan, RM & Mintz, M 2008, 'Atomoxetine treatment of ADHD in children with comorbid tourette syndrome', Journal of Attention Disorders, vol. 11, no. 4, pp. 470-481. https://doi.org/10.1177/1087054707306109

TY - JOUR

T1 - Atomoxetine treatment of ADHD in children with comorbid tourette syndrome

AU - Spencer, Thomas J.

AU - Sallee, F. Randy

AU - Gilbert, Donald L.

AU - Dunn, David W.

AU - McCracken, James T.

AU - Coffey, Barbara J.

AU - Budman, Cathy L.

AU - Ricardi, Randall K.

AU - Leonard, Henrietta L.

AU - Allen, Albert J.

AU - Milton, Denai R.

AU - Feldman, Peter D.

AU - Kelsey, Douglas K.

AU - Geller, Daniel A.

AU - Linder, Steven L.

AU - Lewis, Donald W.

AU - Winner, Paul K.

AU - Kurlan, Roger M.

AU - Mintz, Mark

PY - 2008/1

Y1 - 2008/1

N2 - Objective: This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS). Method: Subjects (7-17 years old) with ADHD (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV) and TS were randomly assigned to double-blind treatment with placebo (n = 56) or atomoxetine (0.5-1.5 mg/kg/day, n = 61) for approximately 18 weeks. Results: Atomoxetine subjects showed significantly greater improvement on ADHD symptom measures. Treatment was also associated with significantly greater reduction of tic severity on two of three measures. Significant increases were seen in mean pulse rate and rates of treatment-emergent nausea, decreased appetite, and decreased body weight. No other clinically relevant treatment differences were observed in any other vital sign, adverse event, laboratory parameter, or electrocardiographic measure. Conclusion: Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS. (J. of Att. Dis. 2008; 11(4) 470-481).

AB - Objective: This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS). Method: Subjects (7-17 years old) with ADHD (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV) and TS were randomly assigned to double-blind treatment with placebo (n = 56) or atomoxetine (0.5-1.5 mg/kg/day, n = 61) for approximately 18 weeks. Results: Atomoxetine subjects showed significantly greater improvement on ADHD symptom measures. Treatment was also associated with significantly greater reduction of tic severity on two of three measures. Significant increases were seen in mean pulse rate and rates of treatment-emergent nausea, decreased appetite, and decreased body weight. No other clinically relevant treatment differences were observed in any other vital sign, adverse event, laboratory parameter, or electrocardiographic measure. Conclusion: Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS. (J. of Att. Dis. 2008; 11(4) 470-481).

KW - ADHD

KW - Atomoxetine

KW - Tic disorders

KW - Tourette syndrome

UR - http://www.scopus.com/inward/record.url?scp=37249077627&partnerID=8YFLogxK

U2 - 10.1177/1087054707306109

DO - 10.1177/1087054707306109

M3 - Article

C2 - 17934184

AN - SCOPUS:37249077627

SN - 1087-0547

VL - 11

SP - 470

EP - 481

JO - Journal of Attention Disorders

JF - Journal of Attention Disorders

IS - 4

ER -

Atomoxetine treatment of ADHD in children with comorbid tourette syndrome

Abstract

Keywords

Access to Document

Fingerprint

Cite this