Atherosclerotic disease is a focal pathological phenomena characterized by the thickening and hardening of the large arteries due to the accumulation of lipids, carbohydrates, blood and blood products, fibrous tissue, and calcium deposits. Significant advances have been made in the last years in the understanding of this phenomena. Epidemiological and experimental studies have identified various so-called 'risk factors' that are frequently present in patients with atherosclerotic disease. Among them, plasma hyperlipidemia seems to play a major role. In spite of the predominant role of cholesterol in the genesis of the disease, thrombotic complications associated with atherosclerotic disease are the major cause of mortality and morbidity in Western civilization. In this review, we will briefly describe the pathogenesis of the disease and the morphological characteristics of arterial lesions. Our main focus, however, will be on the role of thrombus and thrombosis in the progression of the atherosclerotic disease.
|Number of pages||13|
|Journal||Cardiovascular Risk Factors|
|State||Published - 1994|