TY - JOUR
T1 - Atherosclerosis
T2 - Recent developments
AU - Björkegren, Johan L.M.
AU - Lusis, Aldons J.
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/5/12
Y1 - 2022/5/12
N2 - Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.
AB - Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.
UR - https://www.scopus.com/pages/publications/85129824511
U2 - 10.1016/j.cell.2022.04.004
DO - 10.1016/j.cell.2022.04.004
M3 - Review article
C2 - 35504280
AN - SCOPUS:85129824511
SN - 0092-8674
VL - 185
SP - 1630
EP - 1645
JO - Cell
JF - Cell
IS - 10
ER -