Atherosclerosis: Recent developments

Johan L.M. Björkegren, Aldons J. Lusis

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.

Original languageEnglish
Pages (from-to)1630-1645
Number of pages16
JournalCell
Volume185
Issue number10
DOIs
StatePublished - 12 May 2022

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