TY - JOUR
T1 - Atherosclerosis
T2 - Recent developments
AU - Björkegren, Johan L.M.
AU - Lusis, Aldons J.
N1 - Funding Information:
We thank our colleagues and students for discussions. A.J.L. particularly thanks Alan Fogelman for introducing him to atherosclerosis research and supporting him through the years. J.B. thanks Anders Hamsten for introducing him to the field of genetics and support in his early career. We thank Rosa Chen for help in the preparation of this manuscript. Our research was supported by funds from the National Institutes of Health ( HL144651 , HL147883 , and HL148110 ) (A.J.L.), the American Heart Association and the Leducq Foundation (A.J.L., J.B.), and the Swedish Research Council ( 2018-02529 ) and Swedish Heart Lung Foundation ( 20170265 ) (J.B.).
Publisher Copyright:
© 2022 The Authors
PY - 2022/5/12
Y1 - 2022/5/12
N2 - Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.
AB - Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.
UR - http://www.scopus.com/inward/record.url?scp=85129824511&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2022.04.004
DO - 10.1016/j.cell.2022.04.004
M3 - Review article
C2 - 35504280
AN - SCOPUS:85129824511
SN - 0092-8674
VL - 185
SP - 1630
EP - 1645
JO - Cell
JF - Cell
IS - 10
ER -