Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography

Nick S. Nurmohamed, Alexander R. van Rosendael, Ibrahim Danad, Quyen Ngo-Metzger, Pam R. Taub, Kausik K. Ray, Gemma Figtree, Marc P. Bonaca, Judith Hsia, Fatima Rodriguez, Alexander T. Sandhu, Koen Nieman, James P. Earls, Udo Hoffmann, Jeroen J. Bax, James K. Min, David J. Maron, Deepak L. Bhatt

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Clinical risk scores based on traditional risk factors of atherosclerosis correlate imprecisely to an individual’s complex pathophysiological predisposition to atherosclerosis and provide limited accuracy for predicting major adverse cardiovascular events (MACE). Over the past two decades, computed tomography scanners and techniques for coronary computed tomography angiography (CCTA) analysis have substantially improved, enabling more precise atherosclerotic plaque quantification and characterization. The accuracy of CCTA for quantifying stenosis and atherosclerosis has been validated in numerous multicentre studies and has shown consistent incremental prognostic value for MACE over the clinical risk spectrum in different populations. Serial CCTA studies have advanced our understanding of vascular biology and atherosclerotic disease progression. The direct disease visualization of CCTA has the potential to be used synergistically with indirect markers of risk to significantly improve prevention of MACE, pending large-scale randomized evaluation.

Original languageEnglish
Pages (from-to)1783-1800
Number of pages18
JournalEuropean Heart Journal
Volume45
Issue number20
DOIs
StatePublished - 21 May 2024

Keywords

  • Atherosclerotic cardiovascular disease
  • Coronary artery disease
  • Coronary computed tomography angiography
  • Major adverse cardiovascular events
  • Prevention

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