ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin

Keyphrases

• Neuronal Death 100%
• Parkin 100%
• Parkinson's Disease Model 100%
• Activating Transcription Factor 4 (ATF4) 100%
• Parkinson's Disease 31%
• 6-hydroxydopamine (6-OHDA) 25%
• 1-methyl-4-phenylpyridinium 18%
• Cell Death 12%
• Cell Survival 12%
• Four-level 12%
• Neuronal PC12 Cells 12%
• Protective Effect 6%
• Transcription Factor 6%
• Protective Behavior 6%
• Protein Level 6%
• MRNA Level 6%
• Neurodegenerative Diseases 6%
• Oxidative Damage 6%
• Patient Relatives 6%
• Parkinson Patients 6%
• Disease-modifying Therapy 6%
• Deleterious Effects 6%
• Substantia Nigra 6%
• Protective Capacity 6%
• Reduced Cell 6%
• Autosomal Recessive Parkinsonism 6%
• Midbrain Dopaminergic Neurons 6%
• Stress Damage 6%
• Endoplasmic Reticulum Stress (ER stress) 6%
• Cellular Models 6%
• Neuromelanin 6%
• Ventral Midbrain 6%
• Parkin Protein 6%
• Relevant Context 6%

Neuroscience

• Parkinson's Disease 100%
• Neuronal Cell Death 100%
• Parkin 100%
• Activating Transcription Factor 4 100%
• MPP+ 18%
• Cell Death 12%
• Cell Survival 12%
• Dopaminergic 12%
• Transcription Factors 6%
• Neurodegenerative Disorder 6%
• Midbrain 6%
• Dopaminergic Neuron 6%
• Substantia nigra 6%
• Oxidopamine 6%
• Endoplasmic Reticulum Stress 6%
• Neuromelanin 6%
• Messenger RNA 6%