Asynchronous combined central and peripheral demyelination (CCPD) in a girl with anti-MOG positivity: A case report and review of the literature

Luca Bosisio; Matteo Gastaldi; Matilde Inglese; Andrea Rossi; Diego Franciotta; Matteo Cataldi; Carmela Leone; Thea Giacomini; Luana Benedetti; Lino Nobili; Maria Margherita Mancardi

doi:10.1016/j.jneuroim.2023.578213

Asynchronous combined central and peripheral demyelination (CCPD) in a girl with anti-MOG positivity: A case report and review of the literature

Luca Bosisio
, Matteo Gastaldi
, Matilde Inglese
, Andrea Rossi
, Diego Franciotta
, Matteo Cataldi
, Carmela Leone
, Thea Giacomini
, Luana Benedetti
, Lino Nobili
, Maria Margherita Mancardi

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The occurrence of combined central and peripheral demyelination (CCPD) is rare, data are limited to small case and cohort studies, mainly concerning adults. In few patients positivity to anti MOG antibody is reported, thus widening the spectrum of anti-MOG associated disorders (MOGAD). We describe a 7-year-old girl with optic neuritis followed 8 years later by peripheral demyelination, with fluctuating anti-MOG antibody positivity at cell-based assay. From the review of the literature, MOGAD-CCPD appear very rare in childhood, especially with asynchronous course. Clinicians should keep this possibility in mind to better define diagnosis in atypical demyelination syndromes, with therapeutical implications.

Original language	English
Article number	578213
Journal	Journal of Neuroimmunology
Volume	384
DOIs	https://doi.org/10.1016/j.jneuroim.2023.578213
State	Published - 15 Nov 2023
Externally published	Yes

Keywords

Acquired demyelinating syndrome - combined central and peripheral demyelination
Anti MOG antibodies
Polyradiculitis

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10.1016/j.jneuroim.2023.578213

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Bosisio, L., Gastaldi, M., Inglese, M., Rossi, A., Franciotta, D., Cataldi, M., Leone, C., Giacomini, T., Benedetti, L., Nobili, L., & Mancardi, M. M. (2023). Asynchronous combined central and peripheral demyelination (CCPD) in a girl with anti-MOG positivity: A case report and review of the literature. Journal of Neuroimmunology, 384, Article 578213. https://doi.org/10.1016/j.jneuroim.2023.578213

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title = "Asynchronous combined central and peripheral demyelination (CCPD) in a girl with anti-MOG positivity: A case report and review of the literature",

abstract = "The occurrence of combined central and peripheral demyelination (CCPD) is rare, data are limited to small case and cohort studies, mainly concerning adults. In few patients positivity to anti MOG antibody is reported, thus widening the spectrum of anti-MOG associated disorders (MOGAD). We describe a 7-year-old girl with optic neuritis followed 8 years later by peripheral demyelination, with fluctuating anti-MOG antibody positivity at cell-based assay. From the review of the literature, MOGAD-CCPD appear very rare in childhood, especially with asynchronous course. Clinicians should keep this possibility in mind to better define diagnosis in atypical demyelination syndromes, with therapeutical implications.",

keywords = "Acquired demyelinating syndrome - combined central and peripheral demyelination, Anti MOG antibodies, Polyradiculitis",

author = "Luca Bosisio and Matteo Gastaldi and Matilde Inglese and Andrea Rossi and Diego Franciotta and Matteo Cataldi and Carmela Leone and Thea Giacomini and Luana Benedetti and Lino Nobili and Mancardi, \{Maria Margherita\}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = nov,

day = "15",

doi = "10.1016/j.jneuroim.2023.578213",

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Bosisio, L, Gastaldi, M, Inglese, M, Rossi, A, Franciotta, D, Cataldi, M, Leone, C, Giacomini, T, Benedetti, L, Nobili, L & Mancardi, MM 2023, 'Asynchronous combined central and peripheral demyelination (CCPD) in a girl with anti-MOG positivity: A case report and review of the literature', Journal of Neuroimmunology, vol. 384, 578213. https://doi.org/10.1016/j.jneuroim.2023.578213

TY - JOUR

T1 - Asynchronous combined central and peripheral demyelination (CCPD) in a girl with anti-MOG positivity

T2 - A case report and review of the literature

AU - Bosisio, Luca

AU - Gastaldi, Matteo

AU - Inglese, Matilde

AU - Rossi, Andrea

AU - Franciotta, Diego

AU - Cataldi, Matteo

AU - Leone, Carmela

AU - Giacomini, Thea

AU - Benedetti, Luana

AU - Nobili, Lino

AU - Mancardi, Maria Margherita

PY - 2023/11/15

Y1 - 2023/11/15

N2 - The occurrence of combined central and peripheral demyelination (CCPD) is rare, data are limited to small case and cohort studies, mainly concerning adults. In few patients positivity to anti MOG antibody is reported, thus widening the spectrum of anti-MOG associated disorders (MOGAD). We describe a 7-year-old girl with optic neuritis followed 8 years later by peripheral demyelination, with fluctuating anti-MOG antibody positivity at cell-based assay. From the review of the literature, MOGAD-CCPD appear very rare in childhood, especially with asynchronous course. Clinicians should keep this possibility in mind to better define diagnosis in atypical demyelination syndromes, with therapeutical implications.

AB - The occurrence of combined central and peripheral demyelination (CCPD) is rare, data are limited to small case and cohort studies, mainly concerning adults. In few patients positivity to anti MOG antibody is reported, thus widening the spectrum of anti-MOG associated disorders (MOGAD). We describe a 7-year-old girl with optic neuritis followed 8 years later by peripheral demyelination, with fluctuating anti-MOG antibody positivity at cell-based assay. From the review of the literature, MOGAD-CCPD appear very rare in childhood, especially with asynchronous course. Clinicians should keep this possibility in mind to better define diagnosis in atypical demyelination syndromes, with therapeutical implications.

KW - Acquired demyelinating syndrome - combined central and peripheral demyelination

KW - Anti MOG antibodies

KW - Polyradiculitis

UR - https://www.scopus.com/pages/publications/85173234186

U2 - 10.1016/j.jneuroim.2023.578213

DO - 10.1016/j.jneuroim.2023.578213

M3 - Article

C2 - 37820535

AN - SCOPUS:85173234186

SN - 0165-5728

VL - 384

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 578213

ER -

Asynchronous combined central and peripheral demyelination (CCPD) in a girl with anti-MOG positivity: A case report and review of the literature

Abstract

Keywords

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