Asymptomatic circulation of HEV71 in Norway

Elisabet Witsø; Gustavo Palacios; Kjersti S. Rønningen; Ondrej Cinek; Diana Janowitz; Marian Rewers; Bjørn Grinde; W. Ian Lipkin

doi:10.1016/j.virusres.2006.07.015

Asymptomatic circulation of HEV71 in Norway

Elisabet Witsø
, Gustavo Palacios
, Kjersti S. Rønningen
, Ondrej Cinek
, Diana Janowitz
, Marian Rewers
, Bjørn Grinde
, W. Ian Lipkin

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Widespread circulation of human enterovirus 71 was discovered in a prospective study of fecal samples obtained from healthy Norwegian children. Molecular characterization of the virus determined that it belonged to genotype C1. Complete sequencing of this strain, HEV71 804/NO/03, revealed differences in the 5′UTR and polymerase with respect to more pathogenic genotypes that may explain its reduced neurovirulence.

Original language	English
Pages (from-to)	19-29
Number of pages	11
Journal	Virus Research
Volume	123
Issue number	1
DOIs	https://doi.org/10.1016/j.virusres.2006.07.015
State	Published - Jan 2007
Externally published	Yes

Keywords

Enterovirus 71
Epidemiology
Molecular typing

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10.1016/j.virusres.2006.07.015

Cite this

@article{ebb59930e5434a86ace2601c0404f775,

title = "Asymptomatic circulation of HEV71 in Norway",

abstract = "Widespread circulation of human enterovirus 71 was discovered in a prospective study of fecal samples obtained from healthy Norwegian children. Molecular characterization of the virus determined that it belonged to genotype C1. Complete sequencing of this strain, HEV71 804/NO/03, revealed differences in the 5′UTR and polymerase with respect to more pathogenic genotypes that may explain its reduced neurovirulence.",

keywords = "Enterovirus 71, Epidemiology, Molecular typing",

author = "Elisabet Wits{\o} and Gustavo Palacios and R{\o}nningen, \{Kjersti S.\} and Ondrej Cinek and Diana Janowitz and Marian Rewers and Bj{\o}rn Grinde and Lipkin, \{W. Ian\}",

note = "Funding Information: This study was supported by grants from the National Institutes of Health (AI55466, AI51292, UO1 NS047537), Norwegian Research Council (155300/320) and Ministry of Education of the Czech Republic (grant no. MSM0021620814). Environmental triggers of type 1 diabetes: the MIDIA study is supported by the Norwegian Research Council (135893/330, 156477/730). We are grateful to Lars Christian Stene at the Norwegian Institute of Public Health for guidance in statistical calculations and to Gabriel {\AA}nestad for information on the clinical data registries.",

year = "2007",

month = jan,

doi = "10.1016/j.virusres.2006.07.015",

language = "English",

volume = "123",

pages = "19--29",

journal = "Virus Research",

issn = "0168-1702",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Asymptomatic circulation of HEV71 in Norway

AU - Witsø, Elisabet

AU - Palacios, Gustavo

AU - Rønningen, Kjersti S.

AU - Cinek, Ondrej

AU - Janowitz, Diana

AU - Rewers, Marian

AU - Grinde, Bjørn

AU - Lipkin, W. Ian

N1 - Funding Information: This study was supported by grants from the National Institutes of Health (AI55466, AI51292, UO1 NS047537), Norwegian Research Council (155300/320) and Ministry of Education of the Czech Republic (grant no. MSM0021620814). Environmental triggers of type 1 diabetes: the MIDIA study is supported by the Norwegian Research Council (135893/330, 156477/730). We are grateful to Lars Christian Stene at the Norwegian Institute of Public Health for guidance in statistical calculations and to Gabriel Ånestad for information on the clinical data registries.

PY - 2007/1

Y1 - 2007/1

N2 - Widespread circulation of human enterovirus 71 was discovered in a prospective study of fecal samples obtained from healthy Norwegian children. Molecular characterization of the virus determined that it belonged to genotype C1. Complete sequencing of this strain, HEV71 804/NO/03, revealed differences in the 5′UTR and polymerase with respect to more pathogenic genotypes that may explain its reduced neurovirulence.

AB - Widespread circulation of human enterovirus 71 was discovered in a prospective study of fecal samples obtained from healthy Norwegian children. Molecular characterization of the virus determined that it belonged to genotype C1. Complete sequencing of this strain, HEV71 804/NO/03, revealed differences in the 5′UTR and polymerase with respect to more pathogenic genotypes that may explain its reduced neurovirulence.

KW - Enterovirus 71

KW - Epidemiology

KW - Molecular typing

UR - https://www.scopus.com/pages/publications/33750996152

U2 - 10.1016/j.virusres.2006.07.015

DO - 10.1016/j.virusres.2006.07.015

M3 - Article

C2 - 16965832

AN - SCOPUS:33750996152

SN - 0168-1702

VL - 123

SP - 19

EP - 29

JO - Virus Research

JF - Virus Research

IS - 1

ER -

Asymptomatic circulation of HEV71 in Norway

Abstract

Keywords

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