Asymmetric multicomponent [C+NC+CC] synthesis of highly functionalized pyrrolidines catalyzed by silver(I)

Philip Garner; H. Ümit Kaniskan; Jieyu Hu; Wiley J. Youngs; Matthew Panzner

doi:10.1021/ol061113b

Asymmetric multicomponent [C+NC+CC] synthesis of highly functionalized pyrrolidines catalyzed by silver(I)

Philip Garner
, H. Ümit Kaniskan
, Jieyu Hu
, Wiley J. Youngs
, Matthew Panzner

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Highly functionalized pyrrolidines are obtained in a single chemical step via a mild, efficient, and selective Ag¹-catalyzed asymmetric [C+NC+CC] coupling process. Oppolzer's camphorsultam enables the desired reaction cascade and provides a reliable means to control the developing stereochemistry and purify the products. This three-component reaction provides unprecedented access to structurally diverse pyrrolidines for both target- and diversity-oriented syntheses.

Original language	English
Pages (from-to)	3647-3650
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	17
DOIs	https://doi.org/10.1021/ol061113b
State	Published - 17 Aug 2006
Externally published	Yes

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10.1021/ol061113b

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title = "Asymmetric multicomponent [C+NC+CC] synthesis of highly functionalized pyrrolidines catalyzed by silver(I)",

abstract = "Highly functionalized pyrrolidines are obtained in a single chemical step via a mild, efficient, and selective Ag1-catalyzed asymmetric [C+NC+CC] coupling process. Oppolzer's camphorsultam enables the desired reaction cascade and provides a reliable means to control the developing stereochemistry and purify the products. This three-component reaction provides unprecedented access to structurally diverse pyrrolidines for both target- and diversity-oriented syntheses.",

author = "Philip Garner and Kaniskan, \{H. {\"U}mit\} and Jieyu Hu and Youngs, \{Wiley J.\} and Matthew Panzner",

year = "2006",

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doi = "10.1021/ol061113b",

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journal = "Organic Letters",

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T1 - Asymmetric multicomponent [C+NC+CC] synthesis of highly functionalized pyrrolidines catalyzed by silver(I)

AU - Garner, Philip

AU - Kaniskan, H. Ümit

AU - Hu, Jieyu

AU - Youngs, Wiley J.

AU - Panzner, Matthew

PY - 2006/8/17

Y1 - 2006/8/17

N2 - Highly functionalized pyrrolidines are obtained in a single chemical step via a mild, efficient, and selective Ag1-catalyzed asymmetric [C+NC+CC] coupling process. Oppolzer's camphorsultam enables the desired reaction cascade and provides a reliable means to control the developing stereochemistry and purify the products. This three-component reaction provides unprecedented access to structurally diverse pyrrolidines for both target- and diversity-oriented syntheses.

AB - Highly functionalized pyrrolidines are obtained in a single chemical step via a mild, efficient, and selective Ag1-catalyzed asymmetric [C+NC+CC] coupling process. Oppolzer's camphorsultam enables the desired reaction cascade and provides a reliable means to control the developing stereochemistry and purify the products. This three-component reaction provides unprecedented access to structurally diverse pyrrolidines for both target- and diversity-oriented syntheses.

UR - https://www.scopus.com/pages/publications/33748589459

U2 - 10.1021/ol061113b

DO - 10.1021/ol061113b

M3 - Article

AN - SCOPUS:33748589459

SN - 1523-7060

VL - 8

SP - 3647

EP - 3650

JO - Organic Letters

JF - Organic Letters

IS - 17

ER -

Asymmetric multicomponent [C+NC+CC] synthesis of highly functionalized pyrrolidines catalyzed by silver(I)

Abstract

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