Asymmetric increase in substance P immunoreactivity in the rat and guinea pig substantia nigra after unilateral neocortical ablation

Constantin Bouras; Philippe G. Vallet; Patrick R. Hof

doi:10.1016/0304-3940(91)90055-X

Asymmetric increase in substance P immunoreactivity in the rat and guinea pig substantia nigra after unilateral neocortical ablation

Constantin Bouras, Philippe G. Vallet, Patrick R. Hof

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Substance P was visualized in the rat and the guine pig basal ganglia, mesencephalon and spinal cord after surgical unilateral cortical ablation. An increased density in substance P-like immunoreactive patterns in the substantia nigra was observed ipsilaterally to the lesioned hemisphere. These results, together with previous observations in cases of Alzheimer's disease presenting with asymmetric cortical atrophy, suggest an influence of the corticostriatal pathway on substance P-like immunoreactivity in these subcortical structures. Finally, these experiments proved to be a reliable animal model for the study of the effects of neocortical lesions on the neuropeptidergic innervation of certain subcortical regions.

Original language	English
Pages (from-to)	53-56
Number of pages	4
Journal	Neuroscience Letters
Volume	133
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90055-X
State	Published - 25 Nov 1991

Keywords

Animal model
Basal ganglia
Degenerative disorder
Immunohistochemistry
Neuropeptide
Substance P
Substantia nigra

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10.1016/0304-3940(91)90055-X

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title = "Asymmetric increase in substance P immunoreactivity in the rat and guinea pig substantia nigra after unilateral neocortical ablation",

abstract = "Substance P was visualized in the rat and the guine pig basal ganglia, mesencephalon and spinal cord after surgical unilateral cortical ablation. An increased density in substance P-like immunoreactive patterns in the substantia nigra was observed ipsilaterally to the lesioned hemisphere. These results, together with previous observations in cases of Alzheimer's disease presenting with asymmetric cortical atrophy, suggest an influence of the corticostriatal pathway on substance P-like immunoreactivity in these subcortical structures. Finally, these experiments proved to be a reliable animal model for the study of the effects of neocortical lesions on the neuropeptidergic innervation of certain subcortical regions.",

keywords = "Animal model, Basal ganglia, Degenerative disorder, Immunohistochemistry, Neuropeptide, Substance P, Substantia nigra",

author = "Constantin Bouras and Vallet, {Philippe G.} and Hof, {Patrick R.}",

note = "Funding Information: We thank M. Surini, B. Greggio, A.-S. Morel, I. Mi-kolajewski, R. Guntern and P.-Y. Vallon for expert technical assistance. Supported in part by the Brookdale Foundation to P.R.H.",

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doi = "10.1016/0304-3940(91)90055-X",

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T1 - Asymmetric increase in substance P immunoreactivity in the rat and guinea pig substantia nigra after unilateral neocortical ablation

AU - Bouras, Constantin

AU - Vallet, Philippe G.

AU - Hof, Patrick R.

N1 - Funding Information: We thank M. Surini, B. Greggio, A.-S. Morel, I. Mi-kolajewski, R. Guntern and P.-Y. Vallon for expert technical assistance. Supported in part by the Brookdale Foundation to P.R.H.

PY - 1991/11/25

Y1 - 1991/11/25

N2 - Substance P was visualized in the rat and the guine pig basal ganglia, mesencephalon and spinal cord after surgical unilateral cortical ablation. An increased density in substance P-like immunoreactive patterns in the substantia nigra was observed ipsilaterally to the lesioned hemisphere. These results, together with previous observations in cases of Alzheimer's disease presenting with asymmetric cortical atrophy, suggest an influence of the corticostriatal pathway on substance P-like immunoreactivity in these subcortical structures. Finally, these experiments proved to be a reliable animal model for the study of the effects of neocortical lesions on the neuropeptidergic innervation of certain subcortical regions.

AB - Substance P was visualized in the rat and the guine pig basal ganglia, mesencephalon and spinal cord after surgical unilateral cortical ablation. An increased density in substance P-like immunoreactive patterns in the substantia nigra was observed ipsilaterally to the lesioned hemisphere. These results, together with previous observations in cases of Alzheimer's disease presenting with asymmetric cortical atrophy, suggest an influence of the corticostriatal pathway on substance P-like immunoreactivity in these subcortical structures. Finally, these experiments proved to be a reliable animal model for the study of the effects of neocortical lesions on the neuropeptidergic innervation of certain subcortical regions.

KW - Animal model

KW - Basal ganglia

KW - Degenerative disorder

KW - Immunohistochemistry

KW - Neuropeptide

KW - Substance P

KW - Substantia nigra

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Asymmetric increase in substance P immunoreactivity in the rat and guinea pig substantia nigra after unilateral neocortical ablation

Abstract

Keywords

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