Asymmetric increase in substance P immunoreactivity in the rat and guinea pig substantia nigra after unilateral neocortical ablation

Constantin Bouras, Philippe G. Vallet, Patrick R. Hof

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Substance P was visualized in the rat and the guine pig basal ganglia, mesencephalon and spinal cord after surgical unilateral cortical ablation. An increased density in substance P-like immunoreactive patterns in the substantia nigra was observed ipsilaterally to the lesioned hemisphere. These results, together with previous observations in cases of Alzheimer's disease presenting with asymmetric cortical atrophy, suggest an influence of the corticostriatal pathway on substance P-like immunoreactivity in these subcortical structures. Finally, these experiments proved to be a reliable animal model for the study of the effects of neocortical lesions on the neuropeptidergic innervation of certain subcortical regions.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalNeuroscience Letters
Volume133
Issue number1
DOIs
StatePublished - 25 Nov 1991

Keywords

  • Animal model
  • Basal ganglia
  • Degenerative disorder
  • Immunohistochemistry
  • Neuropeptide
  • Substance P
  • Substantia nigra

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