Abstract
Addiction is a leading cause of disease burden worldwide and remains a challenge in current neuroscience research. Drug-induced lasting changes in gene expression are mediated by transcriptional and epigenetic regulation in the brain and are thought to underlie behavioral adaptations. Emerging evidence implicates astrocytes in regulating drug-seeking behaviors and demonstrates robust transcriptional response to several substances of abuse. This review focuses on the astrocytic transcriptional and epigenetic mechanisms of drug action.
| Original language | English |
|---|---|
| Pages (from-to) | 409-424 |
| Number of pages | 16 |
| Journal | Journal of Neural Transmission |
| Volume | 131 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2024 |
Keywords
- alcohol
- cannabinoids
- cocaine
- glia
- nicotine
- opioids