Astrocytes have no CLU they contribute to Alzheimer's disease

Lucrezia Floro; Julia TCW

doi:10.1016/j.neuron.2025.05.011

Astrocytes have no CLU they contribute to Alzheimer's disease

Lucrezia Floro
, Julia TCW

Research output: Contribution to journal › Comment/debate

Abstract

Clusterin (CLU) is a recognized genetic risk factor for Alzheimer's disease. In this issue of Neuron, Lish et al.¹ found that lower CLU levels in astrocytes, caused by the CLU risk allele, heightened inflammation and reduced synaptic functions, potentially increasing risk for cognitive decline.

Original language	English
Pages (from-to)	1849-1851
Number of pages	3
Journal	Neuron
Volume	113
Issue number	12
DOIs	https://doi.org/10.1016/j.neuron.2025.05.011
State	Published - 18 Jun 2025
Externally published	Yes

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10.1016/j.neuron.2025.05.011

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title = "Astrocytes have no CLU they contribute to Alzheimer's disease",

abstract = "Clusterin (CLU) is a recognized genetic risk factor for Alzheimer's disease. In this issue of Neuron, Lish et al.1 found that lower CLU levels in astrocytes, caused by the CLU risk allele, heightened inflammation and reduced synaptic functions, potentially increasing risk for cognitive decline.",

author = "Lucrezia Floro and Julia TCW",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

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day = "18",

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T1 - Astrocytes have no CLU they contribute to Alzheimer's disease

AU - Floro, Lucrezia

AU - TCW, Julia

PY - 2025/6/18

Y1 - 2025/6/18

N2 - Clusterin (CLU) is a recognized genetic risk factor for Alzheimer's disease. In this issue of Neuron, Lish et al.1 found that lower CLU levels in astrocytes, caused by the CLU risk allele, heightened inflammation and reduced synaptic functions, potentially increasing risk for cognitive decline.

AB - Clusterin (CLU) is a recognized genetic risk factor for Alzheimer's disease. In this issue of Neuron, Lish et al.1 found that lower CLU levels in astrocytes, caused by the CLU risk allele, heightened inflammation and reduced synaptic functions, potentially increasing risk for cognitive decline.

UR - https://www.scopus.com/pages/publications/105007852339

U2 - 10.1016/j.neuron.2025.05.011

DO - 10.1016/j.neuron.2025.05.011

M3 - Comment/debate

AN - SCOPUS:105007852339

SN - 0896-6273

VL - 113

SP - 1849

EP - 1851

JO - Neuron

JF - Neuron

IS - 12

ER -

Astrocytes have no CLU they contribute to Alzheimer's disease

Abstract

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