Astrocyte elevated gene 1 interacts with acetyltransferase p300 and c-Jun to promote tumor aggressiveness

Liping Liu, Hongyu Guan, Yun Li, Zhe Ying, Jueheng Wu, Xun Zhu, Libing Song, Jun Li, Mengfeng Li

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Astrocyte elevated gene 1 (AEG-1) is an oncoprotein that strongly promotes the development and progression of cancers. However, the detailed underlying mechanisms through which AEG-1 enhances tumor development and progression remain to be determined. In this study, we identified c-Jun and p300 to be novel interacting partners of AEG-1 in gliomas. AEG-1 promoted c-Jun transcriptional activity by interacting with the c-Jun/p300 complex and inducing c-Jun acetylation. Furthermore, the AEG-1/c-Jun/p300 complex was found to bind the promoter of c-Jun downstream targeted genes, consequently establishing an acetylated chromatin state that favors transcriptional activation. Importantly, AEG-1/p300-mediated c-Jun acetylation resulted in the development of a more aggressive malignant phenotype in gliomas through a drastic increase in glioma cell proliferation and angiogenesis in vitro and in vivo. Consistently, the AEG-1 expression levels in clinical glioma specimens correlated with the status of c-Jun activation. Taken together, our results suggest that AEG-1 mediates a novel epigenetic mechanism that enhances c-Jun transcriptional activity to induce glioma progression and that AEG-1 might be a novel, potential target for the treatment of gliomas.

Original languageEnglish
Article numbere00456-16
JournalMolecular and Cellular Biology
Issue number5
StatePublished - 2017
Externally publishedYes


  • Acetylation
  • Astrocyte elevated gene 1 (AEG-1)
  • C-jun transcription factor
  • E1A binding protein p300 (p300)
  • Glioma


Dive into the research topics of 'Astrocyte elevated gene 1 interacts with acetyltransferase p300 and c-Jun to promote tumor aggressiveness'. Together they form a unique fingerprint.

Cite this