Asthma Epigenetics: Elucidating an Expanding Paradigm

Rachel L. Miller; James Chen

doi:10.1007/978-3-030-94475-9_16

Asthma Epigenetics: Elucidating an Expanding Paradigm

Rachel L. Miller
, James Chen

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This chapter will cover key concepts related to epigenetic regulation of asthma and the disease’s environmental triggers, development, underlying immune pathways, and clinical course. Recent studies that include epigenetic mediation of the effects of exposures on risk factors on asthma will be stressed. Epigenetic regulation of asthma treatments and patient responses to interventions will be described. Among these topics, emphasis will be placed on the time windows of susceptibility. In general, this review suggests that despite continuing progress in this field, further rigorous studies of epigenetic mechanisms in asthma and its management are needed. Future studies may consider the temporality and duration of epigenetic regulation to strengthen the evolving understandings of epigenetics in asthma.

Original language	English
Title of host publication	Epigenetic Epidemiology
Subtitle of host publication	Second Edition
Publisher	Springer International Publishing
Pages	381-404
Number of pages	24
ISBN (Electronic)	9783030944759
ISBN (Print)	9783030944742
DOIs	https://doi.org/10.1007/978-3-030-94475-9_16
State	Published - 1 Jan 2022

Keywords

Airway inflammation
Asthma
DNA methylation
Environmental epigenetics
Histone modification
miRNA

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10.1007/978-3-030-94475-9_16

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abstract = "This chapter will cover key concepts related to epigenetic regulation of asthma and the disease{\textquoteright}s environmental triggers, development, underlying immune pathways, and clinical course. Recent studies that include epigenetic mediation of the effects of exposures on risk factors on asthma will be stressed. Epigenetic regulation of asthma treatments and patient responses to interventions will be described. Among these topics, emphasis will be placed on the time windows of susceptibility. In general, this review suggests that despite continuing progress in this field, further rigorous studies of epigenetic mechanisms in asthma and its management are needed. Future studies may consider the temporality and duration of epigenetic regulation to strengthen the evolving understandings of epigenetics in asthma.",

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N2 - This chapter will cover key concepts related to epigenetic regulation of asthma and the disease’s environmental triggers, development, underlying immune pathways, and clinical course. Recent studies that include epigenetic mediation of the effects of exposures on risk factors on asthma will be stressed. Epigenetic regulation of asthma treatments and patient responses to interventions will be described. Among these topics, emphasis will be placed on the time windows of susceptibility. In general, this review suggests that despite continuing progress in this field, further rigorous studies of epigenetic mechanisms in asthma and its management are needed. Future studies may consider the temporality and duration of epigenetic regulation to strengthen the evolving understandings of epigenetics in asthma.

AB - This chapter will cover key concepts related to epigenetic regulation of asthma and the disease’s environmental triggers, development, underlying immune pathways, and clinical course. Recent studies that include epigenetic mediation of the effects of exposures on risk factors on asthma will be stressed. Epigenetic regulation of asthma treatments and patient responses to interventions will be described. Among these topics, emphasis will be placed on the time windows of susceptibility. In general, this review suggests that despite continuing progress in this field, further rigorous studies of epigenetic mechanisms in asthma and its management are needed. Future studies may consider the temporality and duration of epigenetic regulation to strengthen the evolving understandings of epigenetics in asthma.

KW - Airway inflammation

KW - Asthma

KW - DNA methylation

KW - Environmental epigenetics

KW - Histone modification

KW - miRNA

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BT - Epigenetic Epidemiology

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Asthma Epigenetics: Elucidating an Expanding Paradigm

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Keywords

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