Asthma Epigenetics: Elucidating an Expanding Paradigm

Rachel L. Miller, James Chen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

This chapter will cover key concepts related to epigenetic regulation of asthma and the disease’s environmental triggers, development, underlying immune pathways, and clinical course. Recent studies that include epigenetic mediation of the effects of exposures on risk factors on asthma will be stressed. Epigenetic regulation of asthma treatments and patient responses to interventions will be described. Among these topics, emphasis will be placed on the time windows of susceptibility. In general, this review suggests that despite continuing progress in this field, further rigorous studies of epigenetic mechanisms in asthma and its management are needed. Future studies may consider the temporality and duration of epigenetic regulation to strengthen the evolving understandings of epigenetics in asthma.

Original languageEnglish
Title of host publicationEpigenetic Epidemiology
Subtitle of host publicationSecond Edition
PublisherSpringer International Publishing
Pages381-404
Number of pages24
ISBN (Electronic)9783030944759
ISBN (Print)9783030944742
DOIs
StatePublished - 1 Jan 2022

Keywords

  • Airway inflammation
  • Asthma
  • DNA methylation
  • Environmental epigenetics
  • Histone modification
  • miRNA

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