Asthma-Chronic Obstructive Pulmonary Disease Overlap

Sunita Sharma, Sandhya Khurana, Alex D. Federman, Juan Wisnivesky, Fernando Holguin

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) defines a subgroup of patients with asthma who have persistent airflow obstruction or patients with COPD who may exhibit variable airflow limitation and/or evidence of type 2 inflammation. Additional investigations are needed to determine whether ACO represents a distinct disorder with unique underlying pathophysiology, whether ACO patients should be managed differently from those with asthma or COPD, and whether the diagnosis affects long-term outcomes. This article presents the data about the clinical features of ACO, the current information regarding the underlying pathophysiology of the syndrome, and current understanding of therapeutic options.

Original languageEnglish
Pages (from-to)565-573
Number of pages9
JournalImmunology and Allergy Clinics of North America
Issue number4
StatePublished - Nov 2020


  • Asthma
  • Asthma-chronic obstructive pulmonary disease overlap
  • Chronic obstructive pulmonary disease
  • Disease severity


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