@article{e9f707eba7e74095aab6c569495a3c76,
title = "Asthma-Chronic Obstructive Pulmonary Disease Overlap",
abstract = "Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) defines a subgroup of patients with asthma who have persistent airflow obstruction or patients with COPD who may exhibit variable airflow limitation and/or evidence of type 2 inflammation. Additional investigations are needed to determine whether ACO represents a distinct disorder with unique underlying pathophysiology, whether ACO patients should be managed differently from those with asthma or COPD, and whether the diagnosis affects long-term outcomes. This article presents the data about the clinical features of ACO, the current information regarding the underlying pathophysiology of the syndrome, and current understanding of therapeutic options.",
keywords = "Asthma, Asthma-chronic obstructive pulmonary disease overlap, Chronic obstructive pulmonary disease, Disease severity",
author = "Sunita Sharma and Sandhya Khurana and Federman, {Alex D.} and Juan Wisnivesky and Fernando Holguin",
note = "Funding Information: S. Khurana has research grants from GlaxoSmithKline and Sanofi and royalties from Spinger that are not related to this work. J. Wisnivesky received consulting honorarium from Banook, GSK, and Sanofi and a research grant from Sanofi. S. Sharma, A.D. Federman, and F. Holguin have nothing to disclose. Funding Information: The authors have nothing to disclose that is, related to this work. S. Khurana has research grants from GlaxoSmithKline and Sanofi and royalties from Spinger that are not related to this work. J. Wisnivesky received consulting honorarium from Banook, GSK, and Sanofi and a research grant from Sanofi. S. Sharma, A.D. Federman, and F. Holguin have nothing to disclose. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = nov,
doi = "10.1016/j.iac.2020.07.002",
language = "English",
volume = "40",
pages = "565--573",
journal = "Immunology and Allergy Clinics of North America",
issn = "0889-8561",
publisher = "W.B. Saunders Ltd",
number = "4",
}