Associations of work hours, job strain, and occupation with endothelial function the Multi-Ethnic Study of Atherosclerosis (MESA)

Luenda E. Charles, Desta Fekedulegn, Paul Landsbergis, Cecil M. Burchfiel, Sherry Baron, Joel D. Kaufman, Karen Hinckley Stukovsky, Kaori Fujishiro, Capri G. Foy, Michael E. Andrew, Ana V.Diez Roux

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objective: To investigate associations of work hours, job control, job demands, job strain, and occupational category with brachial artery flowmediated dilation (FMD) in 1499 Multi-Ethnic Study of Atherosclerosis participants.

Methods: Flow-mediated dilation was obtained using highresolution ultrasound. Mean values of FMD were examined across categories of occupation, work hours, and the other exposures using regression analyses.

Results: Occupational category was significantly associated with FMD overall, with blue-collar workers showing the lowest mean values- management/professional =4.97 ± 0.22%; sales/office =5.19 ± 0.28%; services =4.73 ± 0.29%; and blue-collar workers =4.01 ± 0.26% (adjusted P < 0.001). There was evidence of effect modification by sex (interaction P =0.031)-significant associations were observed among women (adjusted P =0.002) and nearly significant results among men (adjusted P =0.087). Other exposures were not significantly associated with FMD.

Conclusions: Differences in endothelial function may account for some of the variation in cardiovascular disease across occupational groups.

Original languageEnglish
Pages (from-to)1153-1160
Number of pages8
JournalJournal of Occupational and Environmental Medicine
Volume56
Issue number11
DOIs
StatePublished - 8 Nov 2014
Externally publishedYes

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